Publicações
2025
A eficácia das escalas de avaliação da saúde mental do escolar: uma revisão sistemática e metanálise
Érica Aparecida Coelho, Thainá Cristina Gonçalves de Aguiar, Emily de Souza Ferreira, Aisllan Diego de Assis, Adriana Maria de Figueiredo, Tiago Ricardo Moreira, Glauce Dias da Costa, Maria Teresa Fialho de Sousa Campos, Rosângela Minardi Mitre Cotta
Hygeia : Revista Brasileira de Geografia Médica e da Saúde, v. 21, p.1-20
DOI: 10.14393/Hygeia2171283
Resumo: Objetivou-se analisar a eficácia das escalas de avaliação da saúde mental do escolar por meio da revisão sistemática e metanálise realizada de acordo com o protocolo Preferred Reporting Items for Systematic Reviews and MetaAnalyses – PRISMA. Realizou-se a pesquisa nas bases de dados Embase, ERIC, PubMed, SciELO, gerando um total de 5683 estudos, desses, 39 foram incluídos na revisão sistemática e 5 na metanálise. Evidenciou-se que as ações de promoção à saúde mental no ambiente escolar produziram efeitos positivos, destacando-se o sentimento de pertencer a escola. A raça e estilo de vida foram associados a fatores psicológicos. O sexo foi relacionado à saúde mental, sobressaindo, na revisão sistemática e metanálise, as meninas como as que apresentaram menor bem-estar e maior ansiedade. Os achados reforçam a necessidade de identificar melhores métodos de triagem para o público escolar, bem como, ressaltam a importância do desenvolvimento e implantação de políticas públicas consistentes direcionadas ao público escolar, em especial às meninas, que considerem as questões de gênero e contextos de vida e que priorizem o encaminhamento humanizado, visando a saúde coletiva, a proteção social e o bem-estar dos escolares que apresentem risco de problemas de saúde mental.
Adiposity and inflammation markers explain mostly part of the plasma zonulin variation in Brazilian adults with overweight/obesity: A cross-sectional analysis from Brazilian nuts study.
Madalena Geralda Cupertino Ribeiro, Ana Claudia Pelissari Kravchychyn, Josefina Bressan, Helen Hermana Miranda Hermsdorff
Clinical Nutrition, v.45, Pp. 22-30
Fator de impacto: 6.6
DOI: 10.1016/j.clnu.2024.12.017
Resumo: Objective: This study evaluated intestinal permeability according to plasma zonulin and its
association with adiposity, inflammation, cardiometabolic risk, liver function, and intestinal health markers in adults with overweight/obesity. Methodology: This study is a cross-sectional analysis using baseline data from the Brazilian Nut Study, which involved 123 participants (93 women, age 33.2 ± 8.58 years, BMI 33.9 ± 4.30kg/m2). Subjects were divided into quartiles according to plasma zonulin, assessed by Elisa. Cytokines were assessed by flow cytometry; anthropometric measurements were collected by standard procedure and body composition was assessed by DXA. SCFA analysis was performed by high-performance liquid chromatography, and fecal pH, by a pH meter. Linear regression models were performed (a<5 %). Results: Participants included in the last quartile of plasma zonulin had higher values of body fat (%), proinflammatory cytokines (CRP, IL-1). According to the multivariate regression model, each one-unit increased in body fat, CRP, IL-12p70, IL-6 and IL-8 resulted correspondingly in an increment of 0.42, 0.14, 0.192, 0.250 and 0.312 ng/ml in plasma zonulin, respectively. Conversely, a one-unit decreased in IL10 led to an increase of 0.40 ng/ml in plasma zonulin. Conclusion: Intestinal permeability assessed by plasma zonulin is associated with adiposity, subclinical inflammation and reduced serum HDL levels adults with overweight/obesity, while adiposity and inflammation markers are independent factors for plasma zonulin variation.
Anti-inflammatory and antioxidant effects of anthocyanins in Nonalcoholic fatty liver disease (NAFLD): a systematic review of in vivo studies
Kelly Aparecida Dias, Lívya Alves Oliveira, Stephanie Michelin Santana Pereira, Lívia Carvalho Sette Abrantes , Laura Célia Oliveira de Souza Vicente , Reggiani Vilela Gonçalves, Ceres Mattos Della Lucia
Critical Reviews in Food Science and Nutrition, v.2025, p.1-18.
Fator de impacto: 7.3
DOI: 10.1080/10408398.2025.2472882
Resumo: Anthocyanins are natural flavonoids, which belong to a group of polyphenols with antioxidant, anti-inflammatory, hypolipidemic and hepatoprotective activities. The aim of this systematic review is to answer the questions “What are the impacts of anthocyanins on inflammatory and oxidative mediators of NAFLD in vivo?” and “What are the possible molecular mechanisms involved in the effects of anthocyanins on NAFLD and hepatic steatosis?” The search was performed at PubMed, Scopus, Web of Science, and Embase databases, and the risk of bias was assessed by the SYRCLE tool. The data analysis was conducted following the PRISMA guidelines. Twenty-three studies performed in animal models evaluating the effects of anthocyanins in inflammatory and oxidative stress mediators in NAFLD were included and evaluated. The anthocyanins demonstrated potential positive effects on inflammation and oxidative stress (OS), in addition to reduced hepatic steatosis. The main results identified were a reduction in TLR, NF-κB, MCP-1/CCL-2, TNF-α, IL-6, and IL-1β in addition to an improvement in antioxidant defense with an increase in Nrf2, SOD, GSH, GPx and CAT and a reduction in OS. The findings from this review provide insights for the development of future studies with anthocyanins on liver health and inflammatory and oxidative parameters. PROSPERO (CRD42024502710).
Aplicabilidade do Indicador Combinado do Status de Vitamina B12 em atendimento ambulatorial de indivíduos vegetarianos
Rafael Junio Rombardi da Silva, Maria Sônia Lopes Duarte, Mariana de Santis Filgueiras, Lisiane Lopes da Conceição, Eliana Carla Gomes de Souza
Revista Científica da FAMINAS, v.19, p. 1-156.
Link
Resumo: Introdução: A deficiência de vitamina B12 possui alta prevalência na população vegetariana. O indicador cB12 representa um método com alta capacidade preditiva, mesmo na ausência de um ou dois biomarcadores ausentes. Objetivo: Objetivou-se investigar a aplicabilidade do indicador cB12 com biomarcadores ausentes no diagnóstico da deficiência de vitamina B12 de indivíduos vegetarianos em nível ambulatorial, bem como analisar a capacidade diagnóstica do ponto de corte proposto para a ferramenta. Material e Métodos: Refere-se a um estudo transversal com uma amostra de indivíduos vegetarianos. Foi avaliado a concordância da deficiência/baixa B12 sérica entre o ponto de corte do indicador cB12 e outros pontos de corte propostos para vitamina B12 sérica. Foi avaliado também a sensibilidade e a especificidade do ponto de corte da ferramenta. Resultados: Observou-se concordância significativa, porém fraca, entre o ponto de corte do indicador cB12 e um dos pontos de corte de vitamina B12 sérica considerados, além de baixa sensibilidade e alta especificidade em relação aos mesmos. Verificou-se resultados parecidos na subamostra de indivíduos vegetarianos não suplementados com vitamina B12, entretanto, observou-se concordância significativa e moderada em relação a um dos pontos de corte de vitamina B12 sérica considerados. Conclusões: Os principais resultados sugerem que essa análise seja realizada em futuros estudos com diferentes amostras e com um maior número de observações para melhor investigação da acurácia do indicador cB12 com biomarcadores ausentes, além da revisão de seu ponto de corte.
Association Between Industrialized Dietary Pattern and Cardiometabolic Risk Factors in Children With FTO RS9939609 Gene Polymorphism
Bhreendda’ Hary Dy Luar Prates Kiepper, Francilene Maria Azevedo, Aline Carare Candido, Mariane Alves Silva, Juliana Farias de Novaes, Cristina Maria Mendes Resende, Danielle Fernandes Durso, Jacqueline Isaura Alvarez-Leite, Gustavo Velasquez-Melendez, Sylvia do Carmo Castro Franceschini, Eliana Carla Gomes de Souza, Sarah Aparecida Vieira Ribeiro
Molecular Nutrition & Food Research,v. 2025, p.1-9.
DOI: 10.1002/mnfr.70254
Fator de impacto: 4.2
Resumo: Dietary patterns may increase cardiometabolic risk, especially in genetically predisposed individuals. Thus, the present study evaluated the association between dietary patterns and cardiometabolic risk factors in children with fat mass and obesity associated (FTO) gene polymorphism. A cross-sectional survey of 258 children aged 4–7 years. Body composition was determined with dual-energy x-ray absorptiometry (DEXA). Biochemical samples and blood pressure were analyzed. Genotyping of rs9939609 was performed using oral swab samples and the TaqMan SNP test. Multiple linear regression stratified by FTO gene categories analyzed the association between dietary patterns and cardiometabolic risk factors. The prevalence of polymorphism was 20.2%. Five dietary patterns were identified: “Traditional”, “Industrialized”, “Milk and chocolate milk”, “Snack”, and “Natural”. Associations were found between the “Industrialized” dietary pattern and both the triglyceride-glucose (TyG) index (β = 0.06; 95% confidence interval [CI]: 0.01–0.11) and triglycerides (β = 7.47; 95% CI: 0.73–14.21) in children with polymorphism. Additionally, “Milk and Chocolate Milk” pattern was associated with the TyG index (β = 0.03; 95% CI: 0.00–0.07) in children with a risk allele. For children with FTO gene polymorphism, adherence to the “Industrialized” dietary pattern was associated with cardiometabolic risk, highlighting the need for nutritional strategies to prevent.
Benefits of Kombucha Consumption: A Systematic Review of Clinical Trials Focused on Microbiota and Metabolic Health
Gabriela Macedo Fraiz, ,Dandara Baia Bonifácio, Rayanne Santos de Paulo, Carolynne Martins Teixeira, Hércia Stampini Duarte Martino, Frederico Augusto Ribeiro de Barros, Fermín I. Milagro, Josefina Bressan
Fermentation, v.11, p. 353 – 381
DOI: 10.3390/fermentation11060353
Fator de imapcto: 3.3
Resumo: Background: Fermented foods rich in bioactive compounds have been proposed as potential strategy to combat non-communicable diseases. Among them is kombucha, a beverage fermented from sugared Camellia sinensis tea by a symbiotic culture of bacteria and yeasts (SCOBY). Recently, there has been an increased focus on assessing the actual effect of this beverage on human health. In this manner, this systematic review aimed to gather clinical evidence on the impact of kombucha consumption on human health. Methods: The databases Cochrane CENTRAL, MEDLINE/PubMed, and Embase® were searched, and the risk of bias tool used was the Critical Appraisal Tools outlined in the Joanna Briggs Institute. This review followed the PRISMA guidelines and was registered on PROSPERO (CRD42024599464). Results: Eight clinical trials were included (two pre- and post-interventions and six randomized controlled trials) with durations ranging from 10 days to 10 weeks. Two studies reported beneficial effects of kombucha on gastrointestinal symptoms, such as reduced intensity of constipation-related complaints. Two trials observed changes in gut microbiota composition, including increased abundance in Bacteroidota, Akkermansiaceae, Saccharomyces, and Weizmannia coagulans, alongside reductions in Ruminococcus, Dorea, and Rhodotorula. Moreover, five clinical trials evaluated glucose metabolism, evidencing inconsistent results, and other studies identified improvements in salivary microbiota composition and serum metabolomic profile. Conclusion: These findings suggest that kombucha consumption may provide health benefits, particularly in alleviating gastrointestinal symptoms, and demonstrates a modest capacity for modulating gut and salivary microbiota, as well as metabolomic profiles. Although the results are promising, the heterogeneity of the studies and the limited number of available clinical trials highlight the need for further robust research to confirm these effects.
Brazil nut consumption within an energyrestricted diet improved cardiometabolic risk markers in women: a quasi-experimental, controlled study (Brazilian Nuts Study)
Alessandra da Silva, Brenda Kelly S. Silveira, Brenda V.M. De Freitas, Karina Waskow, Helen Hermana M. Hermsdorff, Walmir Da Silva, Josefina Bressan
Anais da Academia Brasileira de Ciências, v. 97, p.1-18
Fator der impacto 1.1
DOI: 10.1590/0001-3765202520240631
Resumo: Consuming functional foods alongside the energy-restricted diet can be a great ally in weight loss and improving cardiometabolic risk factors. Whether Brazil nut (BN) consumption in the context of energy restriction affects them remains to be answered. We aimed to evaluate the effect of BN within an energy-restricted diet on cardiometabolic risk markers among women. This is an eight-week, quasi-experimental, controlled nutritional intervention study. The women were allocated into two energyrestricted (-500 kcal/d) groups: a control free of BN (n=29) and a BN-group (BNG) (n=27)
with 2 units/day of BN (~ 347 µg of selenium). Both groups had similar weight loss, but in the BNG, the serum selenium increased by 276.7% and apolipoprotein A1 increased by 27.4%. In addition, BNG had a more pronounced reduction in liver enzymes, and presented the most preserved percentages of lean and fat-free mass in relation to the control group. Consuming 2 units/day of BN in an 8-week weight loss intervention improved cardiometabolic risk markers in women. Our results suggest that regular consumption of BN during energy-restricted diets may be a strategy to minimize adiposity, preserve
lean mass, improve serum selenium status, lipid, and liver metabolism markers, and, consequently, help obesity management and its comorbidities
Can physical exercise modify intestinal integrity and gut microbiota composition? A systematic review of in vivo studies.
Stephanie Michelin Santana Pereira, Vinícius Parzanini Brilhante de São José, Alessandra da Silva, Karina Vitoria Cipriana Martins, Luciano Bernardes Leite, Pedro Forte, Antônio José Natali, Hércia Stampini Duarte Martino, Ceres Mattos Della Lucia, Josefina Bressan
Biology of Sport, v. 42, p. 13-28
Fator de impacto: 4.2
DOI: 10.5114/biolsport.2025.148545
Resumo: There is little evidence about how physical exercise affects the gut microbiota since studies in
the field are relatively recent. Thus, we aimed to systematically review the main effects of regular physical
exercise on the intestinal integrity and microbiota composition in animal models, discuss the mechanisms
involved, and indicate future directions. Searches for original articles were performed in PubMed/MEDLINE, Scopus, Web of Science, and Embase. A total of 18 studies were selected. These studies suggest that physical exercise has a significant impact on the gut microbiota. Voluntary running increased the thickness of duodenal villi and microbiota diversity but reduced its richness. Low-intensity treadmill running increased the abundance of the phylum Actinobacteria and the family Bifidobacteriaceae, while that of moderate-intensity reduced the Bacteroides/Prevotella ratio. High-intensity swimming and treadmill running altered the gut microbiota, evidenced by β-diversity, and increased the Shannon and Chao indices but reduced short-chain fatty acids. Resistance exercise increased the Chao index and altered the functionality of the gut microbiota, increasing carbohydrate
metabolism and reducing lipid and amino acid metabolism. Thus, regular physical exercise of different intensities and types can modify the gut microbiota, and the exercise benefits appear to be positively associated with training intensity.
Cashew Nut Oil Improves Lipid Metabolism and Fat Liver Deposition in High-Fat Diet-Fed C57BL/6J Mice
Marcella Duarte Villas Mishima, Andressa Ladeira Bernardes, Carlos Alexandre Pinheiro, Luisa Gouveia Lana, Iasmim Xisto Campos, Valéria Silva de Lana, Izabela Maria Montezano de Carvalho, Patrícia Fontes Pinheiro, Renata Celi Lopes Toledo, Ana Paula Dionísio, Helen Hermana Hermsdorff, Maria do Carmo Gouveia Peluzio
Lipids, v. 2025, p.1-12.
DOI: 10.1002/lipd.70015
Fator de impacto: 1.6
Resumo: Cashew nut oil adds value to the production chain of this Brazilian oilseed. It is a good source of monounsaturated and polyunsaturated fatty acids and bioactive compounds, such as phenolics. This study investigated the effects of cashew nut oil on the metabolism of animals subjected to a high-fat diet. C57BL/6J mice were fed a high-fat diet (12 weeks), then switched to diets containing cashew nut oil, soybean oil, or lard (12 weeks). Diets were characterized for their fatty acid profile. General parameters, metabolic markers, oxidative stress, gene expression, and liver steatosis were evaluated. Oleic acid was predominant in the cashew nut oil-added diet, linoleic acid in the soybean oil-added diet, and palmitic acid in the lard-added diet. Cashew nut oil reduced blood glucose, triglycerides, uric acid, and liver steatosis, and increased SOD expression and activity and catalase activity. Soybean oil reduced blood glucose, total cholesterol, LDL cholesterol, triglycerides, and liver steatosis. Both vegetable oils, rich in unsaturated fatty acids, demonstrated more benefits than animal fat. Cashew nut oil effects may be mediated by the reduction of hepatic fat accumulation and oxidative stress, leading to lower triglyceride levels, improved insulin signaling, and decreased uric acid, probably due to its fatty acid composition, rich in oleic acid. Phenolic compounds may enhance its antioxidant capacity. The quality of fatty acids and the bioactive compounds is a determinant of the metabolic effect of oils. Cashew nut oil may improve lipid metabolism, reduce liver steatosis, and enhance antioxidant effects.
Comorbidities and Sociodemographic Factors as Determinants of COVID-19 Outcome in Hospitalized Pregnant Women in Brazil
Francilene Maria Azevedo, Ariane Ribeiro de Freitas, Núbia de Souza de Morais, Sarah Aparecida Vieira Ribeiro, Silvia Eloiza Priore, Jackson Martins Rodrigues, Sylvia do Carmo Castro Franceschini.
Archives of Medical Research, v. 56, p. 103184 – 103192.
Fator de impacto: 4.7
DOI: 10.1016/j.arcmed.2025.103184
Resumo: Introduction. SARS-CoV-2 infection during pregnancy causes maternal health complications.
Objective. To investigate the relationship between comorbidities and sociodemographic factors with COVID-19 outcome (death/healing) among hospitalized pregnant women in Brazil. Methodology. A longitudinal study, based on secondary data from the SIVEP Gripe. All hospitalizations of adult pregnant women with COVID-19 were assessed, with a total sample of 16,202 women. The dependent variable was the evolution of COVID19 hospitalizations (death/healing), and the independent variables were age, ethnicity, gestational trimester, immunization, and comorbidities. R software version 4.3.2 was used to analyze the data. Descriptive statistics, the χ2 test, and Poisson regression were used. Joinpoint regression analysis was used to assess trends in lethality during the pandemic. Results. The median age of the pregnant women assessed was 30 years (P25- 25; P75-35). Lethality was 7.62 % (n = 1,236), and death was associated with the group of women who did not receive any dose of vaccine in the second trimester of pregnancy, were aged ≥35 years, and had black/brown skin color. The risk of death was higher among unvaccinated women (RR: 4.29; CI: 2.97–6.50), those aged ≥35 years (RR: 1.37; CI: 1.13–1.67), and those with obesity (RR: 2.08; CI: 1.66–2.58). In the temporal analysis, the monthly percentage change (MPC) in lethality was significant in three periods. Conclusion. Black ethnicity, obesity, and lack of vaccination were the main factors that increased the risk of death from COVID-19 among pregnant women.
Consumption of methyl donor nutrients and incidence of obesity: is the association influenced by parent’s obesity? Results of 4 years of follow-up of the CUME study
Carolynne Martins Teixeira, Josefina Bressan, Leidjaira Lopes Juvanhol, Arieta Carla Gualandi Leal, Adriano Marçal Pimenta & Helen Hermana Miranda Hermsdorff
International Journal of Obesity, v.2025
DOI: 10.1038/s41366-025-01834-1
Fator de imapcto: 3.8
Resumo: Introduction. DNA methylation is labile to the consumption of methyl donor nutrients (MetD), and may modulate gene expression associated with obesity. Objective. To evaluate the association between MetD consumption and the incidence of obesity, as well as to test the modifying role of the effect of the family history of the disease in this association. Methodology. This longitudinal study, with 1205 participants of the Cohort of Universities of Minas Gerais (CUME study), evaluated the incidence of obesity in a 4-year follow-up (2016– 2020). The intake of MetD nutrients (B2, B6, B9, B12, choline, betaine, and methionine) was estimated through a semi-quantitative food frequency questionnaire validated for the population. A MetD score was calculated and later stratified into low, intermediate, and high scores according to the tertiles of the sample. The presence of father and mother with obesity and parental obesity (father and mother with the disease) was self-reported. Associations were tested by Cox regression. Results. 89 (7.4%) cases of obesity were identified during follow-up. Participants who were in the third quartile of B2 consumption and the second quartile of B9 and choline consumption presented 60% (95%CI: 0.20–0.79), 52% (95%CI: 0.26–0.89) and 52% (95%CI: 0.24–0.93) less risk of developing obesity, respectively. Presenting an intermediate MetD score was also associated with a lower risk for the outcome (HR: 0.40; 95%CI: 0.18–0.84). However, the association between high MetD score and obesity incidence was observed only among individuals with a history of the disease in the father (HR: 0.19; 95%CI: 0.03–0.98; p-interaction = 0.022). Conclusion. Intermediate consumption of B2, B9, and choline was associated with a lower risk of obesity, while a high MetD score was associated with reduced risk of outcome in those with a history of paternal obesity.
Construção e validação de instrutivo para o cuidado nutricional da pessoa com obesidade grave no Sistema Único de Saúde
Mariana de Moura e Dias, Olívia Gonçalves Leão Coelho, Flávia Galvão Cândido, Helen Hermana Miranda Hermsdorf
Ciencia & Saude Coletiva, v. 30, p. 30-42
Fator de impacto: 1.1
DOI: 10.1590/1413-81232025301.05572023
Resumo: O artigo descreve a construção e a validação de um instrutivo destinado ao cuidado nutricional de pessoas com obesidade grave no Sistema Único de Saúde (SUS). Na construção do instrutivo, uma ampla revisão de literatura foi realizada para identificação e discussão dos tópicos a serem abordados. As validações de conteúdo e aparente se deram mediante técnica Delphi e grupos focais, respectivamente, com juízes nutricionistas especialistas e práticos de todas as regiões do Brasil. De acordo com a técnica Delphi, os atributos do instrutivo e seu conteúdo como um todo foram avaliados como adequadamente e suficientemente abordados, mediante valores obtidos para o índice de validade de conteúdo (IVC > 0,8). Nos grupos focais, atingiu-se a saturação de conteúdo. Além disso, discussões alinhadas com a realidade do SUS foram conduzidas e, posteriormente, incorporadas ao instrutivo, para adequar a versão final às necessidades dos profissionais do SUS. Em conclusão, o instrutivo construído para preencher uma lacuna sobre o cuidado nutricional da pessoa com obesidade grave apresenta conteúdo adequado em qualidade e tópicos de interesse (validação de conteúdo), aplicável dentro da realidade do(s) nutricionistas do SUS (validade aparente).
Dietary inflammatory index (DII) and telomere length: a systematic review
Joice da Silva Castro, Carolynne Martins Teixeira, Daniela Mayumi Usuda Prado Rocha, Andréia Queiroz Ribeiro, Ana Claudia Pelissari Kravchychyn, Helen Hermana Miranda Hermsdorff
Biogerontology, v. 26, p. 1-16
Fator de impacto: 4.4
DOI: doi.org/10.1007/s10522-025-10237-8
Resumo: Dietary intake influences inflammation and may impact telomere length (TL), a biomarker of biological aging. However, the relationship between the inflammatory potential of the diet and TL remains unclear. This review systematically assessed whether higher Dietary Inflammatory Index (DII) scores, indicative of pro-inflammatory diets, are associated with shorter TL. Searches in PubMed, Embase, Scopus, Web of Science, and Cochrane up to October 2024 identified nine eligible studies, involving 123,923 participants (53% women), aged 9–80 years. Seven studies were cross-sectional, and two were longitudinal, with follow-ups of 5–10 years. Most studies (n = 4) examined adult and older adult populations of both sexes. DII values ranged from -6.48 (anti-inflammatory) to 3.98 (pro-inflammatory). None included all DII parameters, and three adjusted for energy intake. Four studies linked higher DII to shorter TL, focusing on European adults with and without cardiovascular risk, healthy American adults, and Chinese older adults with mild cognitive impairment. This systematic review presents limited data to provide a definitive conclusion on the association between higher DII and shorter TL. Additional studies that address the limitations identified in this review are needed.
Disponibilidade domiciliar de alimentos por grau de processamento e formas de aquisição no Brasil: uma análise da interferência socioeconômica e territorial
Luiza Veloso Dutra, Leidjaira Juvanhol Lopes, Cristiana Tristão Rodrigue, Sylvia do Carmo Castro Franceschini, Juliana Farias de Novaes, Letícia Lopes Vieira, Silvia Eloiza Priore
Segurança Alimentar e Nutricional, v. 2025, p. 1-17
DOI: 10.20396/san.v31i00.8677378
Resumo: Objetivo: Analisar a associação entre o grau de processamento dos alimentos e as formas de aquisição nos domicílios, segundo área, macrorregião e renda. Metodologia: Estudo transversal com dados de aquisição alimentar de 55.970 domicílios brasileiros da Pesquisa de Orçamentos Familiares 2008/09. As formas de aquisição foram categorizadas em monetária (compra), não monetária (doação e outros) e não monetária (produção para autoconsumo), avaliadas por meio de registro de aquisições de sete dias. Os alimentos foram convertidos em calorias e classificados conforme a classificação NOVA, e os domicílios analisados por área, macrorregião e tercil de renda. Resultados: Em todas as regiões, a compra foi a principal forma de aquisição de alimentos, com destaque para alimentos in natura e minimamente processados. A proporção de ultraprocessados adquiridos por compra aumentou em domicílios de maior renda, enquanto a aquisição de alimentos in natura diminuiu. As aquisições por produção para autoconsumo e doação e outros foram mais frequentes em áreas rurais, especialmente a produção para autoconsumo de alimentos in natura, com maior prevalência nas regiões Norte e Sul e entre classes de renda mais altas. Conclusão: A compra é a principal forma de aquisição nos domicílios. Em domicílios com produção para autoconsumo (principalmente em áreas rurais e na região Norte), há maior disponibilidade de alimentos in natura. Questões relacionadas ao sistema alimentar estão entrelaçadas com as formas de aquisição, sendo um campo estratégico para promover modelos de produção socialmente equitativos e sustentáveis, além de facilitar o acesso a uma alimentação adequada e saudável.
Effect of consumption of Brazilian berries on intestinal health: a systematic review of in vivo studies
Lívia Carvalho Sette Abrantes, Lívya Alves Oliveira, Kelly Aparecida Dias, Thaís Cupertino Fialho, Karina Vitória Cipriana Martins, Stefany da Silva Paes, Gabrieli Fernandes Lacerda, Keveni Vitória Dos Santos Nazário, Stephanie Michelin Santana Pereira, Ceres Mattos Della Lucia
Critical Reviews in Food Science and Nutrition, v.35, p.1-15.
DOI: 10.1080/10408398.2025.2540498
Fator de impacto: 8.8
Resumo: Brazilian berries—such as jabuticaba, açaí, camu-camu, acerola, and other native species—have attracted growing interest due to their richness in polyphenols (anthocyanins, flavonoids, phenolic acids), vitamin C, dietary fiber, and other nutrients. Nevertheless, many of these fruits remain underexplored or poorly known in the scientific literature. This systematic review aimed to answer the following questions: “How does the consumption of Brazilian berries influence gut health in vivo?” and “What are the main mechanisms involved in this process?” A comprehensive literature search was conducted in the PubMed, Scopus, Web of Science, and Embase databases, following PRISMA guidelines. Fourteen studies were included, and the risk of bias was assessed using the SYRCLE tool. The main findings indicated improvements in gut microbiota balance, with increased populations of Lactobacillus and Bifidobacterium and a reduction in the Firmicutes/Bacteroidetes ratio. Beneficial effects were also observed on intestinal barrier integrity, including increased expression of Mucin-2 and Claudin-1, and maintenance of Zonula occludens-1 and Claudin-3 levels. An increased SCFA production, a reduction in intestinal inflammation, and modulation of oxidative stress were reported. These findings highlight the potential of Brazilian berries as allies in nutritional and therapeutic strategies aimed at promoting gut health. PROSPERO registration: CRD42024537558.
Effect of Nut Consumption on Human Gene Expression: A Systematic Review of Clinical Trials
Aline Lage Wendling, Madalena Geralda Cupertino Ribeiro, Ana Claudia Pelissari Kravchychyn, Helen Hermana Miranda Hermsdorff
Nutrition Reviews, v. 2025, p.1-16
Fator de impacto: 5.9
DOI: 10.1093/nutrit/nuaf023
Resumo: Context. The consumption of nuts has beneficial effects on cardiovascular health, body composition, cognitive functions, the intestinal microbiota, and satiety control, but how nuts and their nutrients impact related gene expression is unclear. Objective. We analyzed the effects of nut consumption on human gene expression as investigated in controlled clinical trials. Data Sources. This systematic review was conducted according to the PRISMA guidelines. The databases used in the search were MEDLINE/PubMed, Embase, and the Cochrane Library. Data Extraction. Randomized and nonrandomized controlled trials conducted to date that evaluated the effect of nut consumption on the mRNA expression of human genes were evaluated according to eligible criteria. Two authors screened and determined the quality of the studies; disagreements were resolved by the third author between May and June 2024. All authors were involved in analyzing the compiled data. Data Analysis. We selected 13 original articles. Most studies evaluated the effects of Brazil nuts, followed by studies using combinations of two or more nuts, with an interventional duration of six weeks to one year. The consumption of hazelnuts and Brazil nuts increased expression in antioxidant-related genes, while beneficial regulation of proinflammatory pathways (tumor necrosis factor – TNF, interleukin-6 – IL-6, and toll-like receptors 2 and 4 – TLR2 and TLR4) was reported after consumption of Brazil nuts. Genes involved in vascular inflammation (eg, ciclooxygenase-2 – COX-2) were downregulated after the consumption of mixed nuts, and the expression of selenoprotein – SELENOP and glutathione peroxidase 1 – GPX1 were regulated according to the presence of single nucleotide polymorphisms after the consumption of Brazil nuts. Finally, pistachio consumption reduced telomere oxidation (telomerase reverse transcriptase – TERT and WD repeat containing antisense to TP53 – WRAP53) and downregulated resistin and IL-6 genes. Conclusion. The consumption of nuts has beneficial effects on human health, modulating gene expression involved in the progression of chronic diseases, with emphasis on the pathways of inflammation, oxidative stress, and cardiovascular health.
Effect of Polyphenol Supplementation on Adiposity: A Systematic Review of Randomized Clinical Trials
Isabella Mendes, Madalena Geralda Cupertino Ribeiro, Layla Fagundes de Souza, Carla de Oliveira Barbosa Rosa, Helen Hermana Miranda Hermsdorff, Josefina Bressan
Current Nutrition Reports, v. 14, p. 1-13.
Fator de impacto: 4.6
DOI: 10.1007/s13668-025-00626-3
Resumo: Purpose of Review The obesity is a multifactorial disease, result of high adiposity and excessive body fat, with closed relation to the development of other chronic disease. The growing obesity-related costs has relevant public health impact. In turn, the polyphenol is a dietary bioactive compound with recognized antioxidant propriety and healthy benefts. The polyphenol supplementation can be a promising strategy for obesity treatment, due to its potential antiadipogenic and metabolic control efects, improving quality of life of this population. This systematic review evaluated the efect of polyphenol supplementation on adiposity in overweight adults and elderly people (Systematic Review Registration: CRD42024586193). Recent Findings Current research demonstrates that polyphenol supplementation resulted in a signifcant decrease in markers of central adiposity (percentage of body fat, fat mass, waist circumference) and visceral adiposity (visceral adipose tissue). The mechanisms may be involved in the activation of lipid turnover pathways, AMPK activation and suppression of transcription factors (SREBPs, PPAR-γ and C/EBP-α) and key enzymes in lipid synthesis in adipose tissue. Furthermore, polyphenol supplementation has also benefcial efects on controlling of blood pressure, blood glucose and lipid profle, contribute to the prevention of other chronic metabolic disorders. Summary Adiposity refers to the distribution of body fat, closely related to cardiometabolic risk, while polyphenols are phytochemicals with potential health-promoting efects. However, the role of these bioactive compounds in controlling adiposity is not well established. This systematic review presents antiadipogenic and metabolic control efects of the dietary polyphenol supplementation. However, there is no consensus on a specifc dosage or form of presentation that generates the best results. Further studies are needed to elucidate better the potential efect of these compounds and related-pathway, to perform clinical validation of their use, and to establish the benefts of their long-term use.
Effect of regular green tea (Camellia sinensis) kombucha consumption on oxidative stress and endothelial health in individuals with excess body weight: a randomized controlled trial
Dandara Baia Bonifácio, Gabriela Macedo Fraiz, Udielle Vermelho Lacerda, Rodrigo Rezende Cardoso, Ana Claudia Pelissari Kravchychyn, Viviana Corich, Alessio Giacomini, Frederico Augusto Ribeiro de Barros, Josefina Bressan
British Journal of Nutrition, v. 134, p. 1-9
DOI: 10.1017/S0007114525103838
Fator de impacto: 3.0
Resumo: Kombucha is a fermented beverage rich in bioactive compounds. This beverage has demonstrated high antioxidant capacity in vitro and experimental animal studies. In this sense, this study aimed to evaluate the effect of daily consumption of green tea kombucha on oxidative stress and endothelial health in individuals with excess body weight. This is a randomized controlled clinical trial, lasting 10 weeks, during which the control group followed a healthy −500 kcal/d energy-restricted diet. In contrast, the kombucha group, in addition to the energy-restricted diet, consumed 200 ml of kombucha green tea daily. This study included men and women aged 18–45 years without chronic diseases. At the beginning and end of the study, fasting blood was collected, and colorimetric assays and immunoassay protocols evaluated markers of oxidative stress and endothelial health. Compared to the control group, kombucha consumption significantly reduced hydrogen peroxide (H2O2) levels (P = 0·007). Initial and final values were as follows: Control group (16·5 v. 15·09 µmol/ml; n 29) and Kombucha group (18·14 v. 14·67 µmol/ml; n 30). The other markers that were evaluated did not change after the kombucha consumption. In conclusion, daily consumption of 200 ml of green tea kombucha for 10 weeks reduces one pro-oxidant marker, without altering other markers of oxidative stress and endothelial health in individuals with excess body weight. Reducing a pro-oxidant marker suggests that kombucha is an antioxidant beverage with promising implications for human health. However, further studies are needed to elucidate other possible beneficial effects on health.
Effects of a Shake with Cashew and Brazil Nuts on Metabolic Response and Oxidative Stress in Individuals with Overweight or Obesity
Mirian Aparecida C. Costa, Daniela Mayumi Usuda Prado Rocha, Ana Paula Silva Caldas, Dandara Bauão Bonifácio, Alessandra da Silva, Sônia Lopes Pinto, Helen Hermana Miranda Hermsdorff, Leandro Licursi de Oliveira, Josefina Bressan
Nutrition Metabolism and Cardiovascular Diseases, v. 35, p. 104131
Fator de impacto: 3.3
DOI: 10.1016/j.numecd.2025.104131
Resumo: Background and Aims. Nuts are recognized for their potential health benefits, yet little is known about their postprandial impact on metabolic responses and oxidative stress. This study aimed to evaluate the acute effect of a shake containing a mixture of 30g cashew nuts (Anacardium occidentale L.) and 15g Brazil nuts (Bertholletia excelsa H.B.K.) on glucose levels, lipid profiles, and oxidative stress markers in individuals with overweight or obesity. Methods and Results. This was a clinical, randomized, controlled, single-blind, crossover study. On two test days, fifteen subjects consumed either a control (absent of nuts) or a test shake. Metabolic biomarkers were analyzed at fasting and 60, 120, and 240 minutes after shake intake. Compared to the control, the shake with nuts promoted specific changes in oxidative stress and metabolic markers. Differences were observed at 120 minutes after beverage consumption regarding superoxide dismutase (SOD) (control: 117.7 ± 14.6 vs. test: 82.1 ± 10.0 U/mL; p<0.05) and at 240 minutes regarding malondialdehyde (MDA) concentrations (control: 5.0 ± 0.2 vs. test: 4.4 ± 0.3 μM/mg; p<0.05). Also, at 240 minutes postprandial, complement C3 and stearic acid concentrations were higher in the test group than in the control, and a positive correlation was observed between them (p<0.05). However, no differences were observed when considering time x intervention. Conclusion. Our findings suggest that cashew and Brazil nuts did not promote acute metabolic changes. We highlight that the mixed nuts decreased lipid peroxidation but did not improve antioxidant status in individuals with overweight or obesity.
Effects of Communication Strategies on Treatment Adherence and Success in Tuberculosis: A Systematic Review and Meta-Analysis
Omar Oliveira Meira, Luiz Gustavo Ribeiro Silva, Raquel Fonseca Sales, Renata Maria Colodette, Lucas Borges Gomes Ferreira Pinto, Emily de Souza Ferreira, Rosângela Minardi Mitre Cotta, Tiago Ricardo Moreira
Tropical Medicine & International Health, v.2025, p.1-16
DOI: 10.1111/tmi.70013
Fator de impacto: 2.3
Resumo: Introduction. Tuberculosis, although curable, presents challenges related to treatment adherence, which compromises treatment effectiveness. Individual, social and structural barriers interfere with patients’ ability to properly follow the therapeutic regimen, thereby impacting treatment outcomes. Given the limitations of the conventional healthcare model, which relies primarily on in-person consultations and standard treatment protocols without additional adherence support technologies, new approaches have been explored to improve patient outcomes. This study seeks to identify effective communication approaches in this context. Objective. To identify the most effective communication strategies to optimise treatment adherence and improve therapeutic success in patients diagnosed with tuberculosis. Methods. A systematic review with meta-analysis was conducted. We included studies available in the MEDLINE (via PubMed), EMBASE and SCOPUS databases, with publication dates between January 2005 and December 2024. The primary outcomes were adherence to and success in tuberculosis treatment. Results. This systematic review included 17 studies on tuberculosis treatment adherence. Of these, 12 were included in the meta-analysis for adherence and 8 for treatment success. The most effective strategies for adherence were community education (2 studies; RR: 0.25, 95% CI: 0.11–0.56) and video observed therapy (VDOT) (2 studies; RR: 0.29, 95% CI: 0.21–0.40). The combination of electronic devices with SMS also showed positive results (3 studies; RR: 0.53, 95% CI: 0.37–0.77). SMS alone (5 studies) and electronic devices alone (3 studies) were not effective. For treatment success, only the combination of electronic devices with SMS (RR: 0.31, 95% CI: 0.17–0.55) and community education (RR: 0.51, 95% CI: 0.40–0.64) were effective. Conclusion. The combination of electronic devices with SMS and community education is an effective strategy for improving adherence and therapeutic success in tuberculosis treatment. Isolated interventions with SMS or electronic technologies did not show significant results. Adapting approaches to local realities is crucial for optimising outcomes.
Estado nutricional de iodo de gestantes brasileiras segundo marcadores bioquímicos e alimentícios: estudo EMDI-Brasil
Aline Carare Candido, Sarah Aparecida Vieira Ribeiro, Poliana Cristina de Almeida Fonseca, Anderson Marliere Navarro, Fabiana de Cássia Carvalho Oliveira, Débora Letícia Frizzi Silva, Edimar Aparecida Filomeno Fontes, Sandra Patricia Crispim, Mariana de Souza Macedo, Sylvia do Carmo Castro Franceschini
Ciência & Saúde Coletiva, v. 30, p. 1-15
DOI: 10.1590/1413-81232025308.04962024
Fator de imapcto: 1.2
Resumo: O objetivo é caracterizar o estado nutricional de iodo das gestantes brasileiras de acordo com marcadores bioquímicos e dietéticos. Trata-se de um estudo transversal realizado com 2.376 gestantes. Para a caracterização da população, foi aplicado um questionário semiestruturado. Amostras de urina foram coletadas para investigar o estado nutricional de iodo e o recordatório de 24 horas foi aplicado para avaliar o consumo de alimentos. Para a análise estatística, foi aplicado o teste de Shapiro-Wilk para verificar o padrão de normalidade e foram realizadas análises descritivas. A concentração mediana de iodo urinário (CIU) foi de 186,6 µg/L. Houve uma prevalência de 36,7% de deficiência de iodo, 28,7% acima da necessidade e 3,6% de excesso de iodo. A concentração mediana de iodo no sal foi de 26,6 mg/kg, nos temperos foi de 1,1 mg/100 g, na água foi de 2,9 µg/L e nos alimentos in natura de 19,4 µg/100 g. A ingestão média de iodo foi de 160,2 µg. Avaliando o consumo alimentar, 49,8% das gestantes tinham ingestão habitual de iodo abaixo de 160 µg e nenhuma tinha ingestão excessiva. A mediana da CIU demonstrou estado nutricional de iodo adequado, mas foi observada alta prevalência de deficiência e de excesso de iodo. Além disso, o estado nutricional de iodo variou, o que pode refletir desigualdades socioeconômicas e de saúde.
Evaluation of mobile health applications using the RE-AIM model: systematic review and meta-analysis
Emanuele Louise Gomes de Magalhães Jorge, Emily de Souza Ferreira, Michele Duarte Pereira, Ana Luiza Paes Mingote, João Henrique Corrêa Silva, Tiago Ricardo Moreira, Rosângela Minardi Mitre Cotta
Frontiers in Public Health, v. 13, p. 1-12
DOI: 10.3389/fpubh.2025.1611789
fator de impacto: 3.4
Resumo: Background: The Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) model has been used as an instrument to determine the impact of the intervention on health in digital format. This study aims to evaluate, through a systematic review and meta-analysis, the dimensions of RE-AIM in interventions carried out by mobile health apps. Methods: The systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and involved searching six databases – Medline/PubMed, Embase, CINAHL, Virtual Library in Health, and Cochrane Library. The review included randomized, cross-sectional, and cohort clinical trials assessing the prevalence of each RE-AIM dimension according to the duration of the intervention in days. The quality of the selected studies was evaluated using the Joanna Briggs Institute tool. The random effects meta-analysis method was used to explain the distribution of effects between the studies, by Stata® software (version 11.0) and publication bias was examined by visual inspection of graphs and Egger’s test. Results: After analyzing the articles found in the databases, and respecting the PRISMA criteria, 21 studies were included, published between 2011 and 2023 in 11 countries. Improvements in health care and self-management were reported for various conditions. The result of the meta-analysis showed a prevalence of 67% (CI: 53–80) for the reach dimension, of 52% (CI: 32–72) for effectiveness, 70% (CI: 58–82) for adoption, 68% (CI: 57–79) for implementation and 64% (CI: 48–80) for maintenance. Conclusion: The RE-AIM dimensions are useful for assessing how digital health interventions have been implemented and reported in the literature. By highlighting the strengths and areas requiring improvement, the study provides important input for the future development of mobile health applications capable of achieving better clinical and health promotion outcomes.
Evidência da efetividade da educação interprofissional em saúde: uma revisão sistemática
Vanessa de Souza Amaral, Lara Camargo de Oliveira, Emily de Souza Ferreira, Tiago Ricardo Moreira, Glauce Dias da Costa e Rosângela Minardi Mitre Cotta
Journal of Management and Primary Health Care, v. 17, p.1-23
DOI: 10.14295/jmphc.2025-v17.1448
Resumo: A Educação Interprofissional em Saúde – EIP é uma abordagem definida como uma relação de aprendizagem e de partilha de conhecimentos entre duas ou mais profissões, com o enfoque na assistência do cuidado qualificado. O objetivo deste estudo é descrever a produção cientifica sobre os métodos de avaliação e a efetividade da Educação Interprofissional em Saúde. A revisão sistemática foi orientada pelo protocolo Preferred Reporting Items for Systematic Reviews and Meta Analysis, a partir, das bases dados: Medical Literature Analysis and Retrieval System Online, Excerpta Medica dataBASE, Science Direct e Education Resources Information Center. Na seleção, não houve restrição temporal, local e/ou idiomática. A qualidade metodológica dos artigos foi mensurada por meio de um instrumento do Joanna Briggs Institute. Resultaram 4.417 estudos, destes, 18 atenderam aos critérios de elegibilidade. A Educação Interprofissional em Saúde aprimora as práticas assistenciais e o contexto de formação em saúde com uma diversidade de estratégias e de métodos para mensuração.
Exploring the role of green tea (Camellia sinensis) in modulating gut microbiota and enhancing intestinal health: a systematic review of human clinical trials.
Gabriela Macedo Fraiz, Aline Rosignoli da Conceição, Dandara Baia Bonifácio, Hércia Stampini Duarte Martino, Frederico Augusto Ribeiro de Barros, Fermín I. Milagro, Josefina Bressan
Food Reviews Iternational, v. 41, p. 1-20
DOI: 10.1080/87559129.2025.2559877
Fator de imapcto: 6.0
Resumo: Plant-based drinks rich in bioactive compounds have emerged as a strategy to enhance intestinal health, such as green tea, notable for its catechin profile. This systematic review aims to critically evaluate existing evidence from human clinical trials on the impact of green tea consumption on intestinal health. It followed the PRISMA guideline and was registered on PROSPERO (CRD42024599100). The searched databases were Cochrane CENTRAL, MEDLINE/Pubmed, and Embase®. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Tools. After removing duplicates and screening, seven articles were included (five randomized controlled trials and two quasi-experimental). Positive changes in gut microbiota composition were revealed, with an increased abundance of short-chain fatty acids producers (Bifidobacterium, Coprococcus, Oscillospiraceae) and a decrease in inflammatory pathobiont (Fusobacterium). Regarding alpha and beta diversity, heterogeneous effects were reported: some studies found improvements in microbial diversity and richness, others did not observe significant changes. Notably, only one study measured endotoxemia, and observed reduced intestinal permeability. Green tea appears to have potential effect on modulating the gut microbial profile, although contrasting findings remain for diversity metrics. Longitudinal studies are needed to provide more robust evidence, particularly concerning intestinal barrier integrity, as only one study has assessed this aspect.
Fluorescent advanced glycation end products contents in foods and culinary preparations
Nélia Pinheiro Mendes, Eliana Carla Gomes de Souza, Leidjaira Juvanhol Lopes, Leandro Licursi de Oliveira, Rita de Cássia Gonçalves Alfenas
Food and Humanity, v. 4, p. 100620 -100627
DOI: 10.1016/j.foohum.2025.100620
Resumo: Total advanced glycation end products (AGEs) content of a food is based on its fluorescent and non-fluorescent AGEs contents. However, fluorescent AGEs contents in foods and food preparations are still unknown. Therefore, in this study we assessed that content by Fluorescence Spectroscopy in triplicate food samples. Fluorescent AGEs contents are higher in processed and ultra-processed foods; and deep-fried, grilled, boiled after stir-fried, oil-free fried (air fryer), barbecue, and roasted foods. While unprocessed foods have high fluorescent AGEs contents when prepared using dry heat; boiled foods, fruits, vegetables, milk, and milk products have low contents. Fluorescent AGEs contents were similar among carbohydrate-, protein-, and fat-rich foods. The results of this study expand the available data on foods fluorescents contents, which can be used in association with the previously published data in clinical studies and clinical practice.
Food Intake According to Clock Gene Polymorphisms: A Systematic Review
Laís Teixeira Campos, Polimar Ferreira Fonseca, Daniela Mayumi Usuda Prado Rocha, Josefina Bressan, Ana Claudia Pelissari Kravchychyn, Helen Hermana Miranda Hermsdorff
FASEB Journal, v.15, p. 1-14
DOI: 10.1096/fj.202500951R
Fator de imapcto: 4.2
Resumo: This systematic review investigated differences in daily energy intake among genotypes of circadian clock genes, potentially supporting personalized nutritional strategies for health. This topic can help develop personalized nutritional strategies for metabolic health by evaluating SNPs in circadian clock genes that may influence dietary intake. We searched the PubMed, EMBASE, and Cochrane Library databases following PRISMA guidelines and assessed the risk of bias using the Joanna Briggs Institute (JBI) tool (PROSPERO: CRD42024601530). Ten studies were included, involving 12,115 adult and elderly participants (mean age 40.8 ± 8.6 years; 60.6% women). Six studies investigated the SNP CLOCK rs1801260, while four analyzed the SNPs CLOCK rs4580704, CLOCK rs3749474, CRY1 rs2287161, and CRY2 rs11605924, with one study for each. Only one study found an association between the minor allele of CLOCK rs1801260 and increased energy, carbohydrate, and lipid intake, as well as later meal timing. Individuals with at least one risk allele (C) had higher intake and later mealtimes than those with the wild-type allele (TT). The inconsistent associations across studies may be attributed to methodological limitations, including dietary assessment, sample size, genetic model classification, population characteristics, and environmental factors, such as including dietary patterns, chronotype, night shift work, sleep, and meal timing. Future research should adopt more comprehensive approaches to better clarify the impact of circadian gene variants on eating behavior.
Germinated and Extruded Sorghum Beverage Presented Good Sensorial Acceptance and Improves Insulin and Satiety in Normoglycemic Adults: An Acute Randomized Controlled Crossover Trial
Lucimar Aguiar da Silva, Vinícius Parzanini Brilhante de São José, Adriane Moreira Machado, Pietra Vidal Cardoso do Prado, Marcela Benevenuto Ferreira, Haira Guedes Lúcio, Renata Celi Lopes Toledo, Flávia Galvão Cândido, Joseph Francis Pierre, Carlos Wanderlei Piler de Carvalho, Valéria Aparecida Vieira Queiroz, Bárbara Pereira da Silva, Hércia Stampini Duarte Martino
Journal of the American Nutrition Association, v. 25, p. 1-12
DOI: 10.1080/27697061.2025.2539424
Fator de imapcto: 2.6
Resumo: Objective. To evaluate the sensorial acceptance of sorghum beverage and its acute effect on the glycemic and insulin and glucagon-like peptide-1 (GLP-1) responses, food consumption, and subjective appetite and satiety sensations in normoglycemic adults. Methods. The sorghum flour was characterized, followed by the development of the beverages and sensory analysis with 60 adults. Subsequently, an acute trial was conducted with 14 normoglycemic individuals, where capillary and venous blood were collected at different time points to assess glycemic, insulinemic and satiety responses. Glycemic index of the beverages, food intake, and subjective appetite sensations were also evaluated. The study was registered in the Brazilian Registry of Clinical Trials (register number: RBR-32v2gm5). Results. The germinated and extruded BRS305 whole sorghum flour presented resistant starch, condensed tannins, and phenolic compounds, which promote important antioxidant activity. Among the developed sorghum beverages, the strawberry-flavored was the most well sensorially accepted and, therefore, selected for an acute clinical study. The sorghum beverage increased GLP-1 and decreased the incremental area under the curve of insulin and the feeling of “hunger” by maintaining the glycemic and improving insulin response in the normoglycemic adults relative to the control beverage. The subjective sensations of “satisfaction” and “fullness” and the composite satiety score were higher at all points of time for the sorghum beverage. Conclusion. Germinated and extruded sorghum beverage presented good nutritional and sensory quality, and its acute consumption improved postprandial insulin and GLP-1 responses, enhanced satiety in normoglycemic adults.
Healthful plant-based diet and incidence of hypertension in Brazilian adults: A six-year follow-up of the CUME study
Fernanda Maria Oliveira da Silva, Adriano Marçal Pimenta, Leidjaira Juvanhol Lopes, Helen Hermana Miranda Hermsdorff, Josefina Bressan
Nutrition, v.133, p. 1-9
Fator de impacto: 3.2
DOI: 10.1016/j.nut.2025.112711
Resumo: Studies demonstrate that consuming plant-based diets has beneficial effects on several health outcomes. However, the evaluation of the healthiness of plant-based diets and the incidence of hypertension has still been little explored in the literature. Objectives: Thus, this study aimed to evaluate the association between plant-based diet indices and the incidence of hypertension in Brazilian adults and test whether the interaction between hPDI, sociodemographic, and lifestyle variables modifies this association. Methods: This longitudinal study included 3192 (F = 2125, average age 34 years) participants from the Cohort of Universities of Minas Gerais (CUME Study, Brazil, 2016-2022). Dietary intakes were assessed using a validated food frequency questionnaire. We measured three plant-based diet indices: overall plant-based diet index (PDI), healthful plant-based diet index (hPDI), and unhealthful plant-based diet index (uPDI). Participants were classified as new cases of hypertension if they were free of this disease at baseline, had a systolic blood pressure ≥ 140 mmHg, a diastolic blood pressure ≥90 mmHg, were using antihypertensive medications, or had a diagnosis of hypertension by a physician in at least one of the follow-ups. Crude and adjusted Cox regression models were used to evaluate the relationship between plant-based diet indices and hypertension incidence and a multiplicative interaction was tested. Results: The incidence of hypertension was 19,8/1000 person-years total. The mean follow-up time was 3.36 years. There was an inverse association between the highest quintiles of hPDI (HR = 0.56, 95% CI = 0.37–0.86; HR = 0.55, 95% CI = 0.35–0.88) and hypertension. In subgroup analysis, inverse associations between hPDI and hypertension risk were stronger in participants who were insufficiently active and overweight (p-interaction < 0.05). Conclusion: Greater consumption of healthful plant foods, reduced consumption of animal-source foods, and less consumption of unhealthful plant foods are important for hypertension prevention in the Brazilian population.
High Body Fat in Normal Weight Girls Was Related to Inflammatory Markers and Cardiometabolic Risk
Ariane Ribeiro de Freitas Rocha, Nubia de Souza de Morais, Francilene Maria Azevedo, Dayane de Castro Morais, Patrícia Feliciano Pereira, Maria do Carmo Gouveia Peluzio, Sylvia do Carmo Castro Franceschini, Silvia Eloiza Priore
Acta Pediatrica, v. 2025, p. 1-7
DOI: 10.1111/apa.70144
Fator de imapcto: 2.1
Resumo: Aim. The aim was to evaluate the relationship between body fat (BF) in girls and inflammatory markers and cardiometabolic risk factors. Methods. This was a cross-sectional study of 555 girls aged 10–19 years. They were divided into three body mass index (BMI) and BF groups: normal BMI/BF, normal BMI/high BF, and overweight or obesity, using the WHO definition. BF was assessed using dual-energy X-ray absorptiometry, considering 25% as a cut-off for high BF. We also evaluated systolic and diastolic blood pressures, lipid profile, fasting glucose, insulin, uric acid levels and inflammatory markers. Results. Excess BF was positively correlated with higher levels of blood pressure (r = 0.323), triglycerides (r = 0.146), uric acid (r = 0.358), leptin (r = 0.712), high-sensitivity C-reactive protein (r = 0.336), insulin (r = 0.258) and markers of insulin resistance (r = 0.265, r = 0.159). It was negatively correlated with high-density lipoprotein cholesterol (r = −0.222). In girls with a normal body mass index, excess BF was correlated with an unfavourable lipid profile and the presence of subclinical inflammation; these were similar to those observed in the girls with obesity. Conclusion. High BF in normal weight girls was related to inflammatory markers and cardiometabolic risk. These assessments are important because inflammation and cardiometabolic risk parameters persist or worsen from adolescence to adulthood.
Insulin resistance mediate the association between leucine intake, dietary glycemic index, and type 2 diabetes in secondary cardiovascular prevention: path analysis from Brazilian cardioprotective nutritional (BALANCE) program
Alinne Paula de Almeida, Leidjaira Juvanhol Lopes, Ângela Cristine Bersch-Ferreira, Camila Ragne Torreglosa, Aline Marcadenti, Bernardete Weber, Josefina Bressan, Helen Hermana Miranda Hermsdorff
European Journal of Nutrition, v. 64, p.1-11.
Fator de impacto: 4.1
DOI: 10.1007/s00394-025-03653-6
Resumo: Purpose Insulin resistance (IR) is an important mediator of the relationship between food intake and the development of type 2 diabetes mellitus (T2DM). Most of the few studies that have evaluated this relationship relied on the triglycerideglucose index (TyG index) tool. Here, we evaluated the association between leucine intake, glycemic index, and T2DM with related mediators in individuals throughout secondary cardiovascular prevention. Methods Sociodemographic, anthropometric, clinical, and food intake data were recorded from the baseline of the trial Brazilian Cardioprotective Nutritional (BALANCE) Program. Path analysis was used to explore the relationships between variables. Results This study enrolled 2,247 participants (median age of 63.0 (45–91) years; 58.8% males). The TyG index showed
positive association with T2DM (SC=0.356; p<0.001) and negative association with leucine intake (SC= -0.046; p=0.028). The glycemic index (GI) was positively associated with BMI (SC=0.072; p=0.001), and BMI had an indirect positive effect on T2DM mediated by the TyG index (SC=0.078; p<0.001). Leucine intake had indirect negative effect on T2DM, mediated by the TyG index (SC= -0.016; p=0.029), while GI had indirect positive effect on T2DM mediated by BMI and TyG index (SC=0.006; p=0.002). Conclusion Leucine intake and GI showed indirect association with T2DM, mediated by TyG and BMI, in individuals on secondary cardiology prevention, reinforcing the importance of assessing food consumption and promotin food quality improvements for cardiometabolic control by different pathway
Interaction between skipping breakfast and depression on the incidence of metabolic syndrome among Brazilian adult graduates: six-year follow-up (CUME Study)
Isabella Mendes, Josefina Bressan, Arieta Carla Gualandi Leal, Andréia Queiroz Ribeiro, Adriano Marçal Pimenta, Helen Hermana Miranda Hermsdorff
Nutrition, Metabolism and Cardiovascular Diseases, v.2025, p.1-9
DOI: 10.1016/j.numecd.2025.104202
Fator de impacto: 3.7
Resumo: Background and aims. Skipping breakfast has been associated with MetS as well as depression. Our aim was to evaluate the association between skipping breakfast and the incidence of MetS in Brazilian adults as well as the potential interaction with depression in this relationship. Methods and results. This longitudinal study included 4.287 participants (M= 1.319 and F= 2.968, mean age of 36 years) from the Cohort of Universities of Minas Gerais (CUME Study). The breakfast frequency was assessed through the baseline questionnaire, using the question “Do you eat breakfast?”. Participants who did not eat breakfast daily were considered as those who skipped breakfast. The incidence of MetS was determined based on self-reported associated risk factors, its absence in Q_0, and its presence as newly identified cases during cohort follow-up at 2, 4, and 6 year. Crude and adjusted Cox regression models were performed. After a mean 6-year follow-up, 215 incident cases of MetS (incidence of 5.0 %) were reported. At baseline, 1.897 (44.25 %) participants skipped breakfast at least once and 521 (12.15 %) cases of depression were identified. Participants who skipped breakfast had a 51 % higher risk of developing MetS (HR: 1.51, 95 % IC: 1.13–2.00) when compared to participants who consumed breakfast daily, after adjusting for confounding factors. Participants with depression who skipped breakfast exhibited a 118% higher risk (HR: 2.18; 95 % CI: 1.11–4.29) of developing MetS compared to those with depression who consumed breakfast daily. Conclusion. Daily breakfast skipping could be a significant risk factor for MetS in Brazilian graduate adults, particularly among those with depression.
Iodine Deficiency and Excess in Brazilian Pregnant Women: A Multicenter Cross-Sectional Study (EMDI-Brazil)
Aline Carare Candido, Francilene Maria Azevedo, Sarah Aparecida Vieira Ribeiro, Anderson Marliere Navarro, Mariana de Souza Macedo, Edimar Aparecida Filomeno Fontes, Sandra Patricia Crispim, Carolina Abreu de Carvalho, Nathalia Pizato, Danielle Góes da Silva, Franciane Rocha de Faria, Jorge Gustavo Velásquez Meléndez, Barbosa Míriam Carmo Rodrigues, Naiara Sperandio, Renata Junqueira Pereira, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini
Nutrients v. 17, p. 2753 -2768
DOI: 10.3390/nu17172753
Fator de imapcto: 5.0
Resumo: Background/Objectives: Iodine is an important nutrient for the human body, used in the production of thyroid hormones. During pregnancy, a deficiency can cause miscarriage and hypothyroidism, while an excess can cause thyroid dysfunction. Therefore, the objective of this study was to evaluate the factors associated with the iodine nutritional status of pregnant Brazilian women. Methods: This was a cross-sectional, multicenter study conducted with pregnant women over 18 years of age, users of the Unified Health System (SUS). A semi-structured questionnaire was used to obtain sociodemographic information. Iodine status was assessed by urinary iodine concentration (UIC). The iodine content of salt and homemade and industrial seasonings was determined by the titrimetric method. Dietary intake was estimated through a 24-hour dietary recall. The chi-square test and hierarchical multinomial logistic regression were used for statistical analysis. The significance level was set at p ≤ 0.05. Results: Among Brazilian pregnant women, the median UIC was 186.7 µg/L (P25: 118.05 µg/L-P75: 280.93 µg/L). Regarding iodine nutritional status, the prevalence of deficiency was 36.7% (n = 694), above the requirement was 28.7% (n = 543), and excess iodine intake was 3.6% (n = 68). We observed that non-white pregnant women were more likely (OR = 1.83; 95% CI: 1.27–2.64) to have iodine deficiency, and those who did not work were less likely (OR = 0.71; 95% CI: 0.52–0.98). Pregnant women in the last trimester of pregnancy were less likely to have iodine intake above the requirements (OR = 0.52; 95% CI: 0.31–0.88). Conclusions: A substantial proportion of pregnant women had iodine deficiency or intake above the required level. Iodine deficiency is more chance among non-white pregnant women and less chance among those not employed during pregnancy. On the other hand, pregnant women who were in their third trimester of pregnancy were less likely to have iodine intake above the required level.
Leptin, CRP, and adiponectin correlate with body fat percentage in adolescents: systematic review and meta-analysis.
Ariane Ribeiro de Freitas Rocha, Nubia de Souza de Morais, Francilene Maria Azevedo, Dayane de Castro Morais, Patrícia Feliciano Pereira, Maria do Carmo Gouveia Peluzio, Sylvia do Carmo Castro Franceschini, Silvia Eloiza Priore
Frontiers in Nutrition, v. 12, p. 1-17
DOI: : 10.3389/fnut.2025.1560080
Fator de impacto: 5.1
Resumo: Introduction: Adipose tissue is important in the secretion of inflammatory substances, and may be directly or indirectly associated to the development of cardiovascular and metabolic diseases in adolescence. Objective: To evaluate whether inflammatory markers are associated to body fat percentage in adolescents. Methodology: Systematic review conducted following the items of the PRISMA, and registered in PROSPERO. The descriptors adolescent, body fat distribution and cytokines were combined together in the electronic databases: Scopus, PubMed, Embase, Cochrane, Scholar Google and ProQuest, independently by two researchers, in January 2022 and atualized in November 2024. Meta-analysis of the correlation of inflammatory markers with body fat percentage was conducted using the metabin function of the meta package of the RStudio software (4.0.4). Results: Resulted in 7,592 records, of which 31 articles met the inclusion criteria and were selected for this study. Cross-sectional and prospective cohort observational studies were included. The meta-analysis included 4,682 adolescents, aged 10 to 19 years, of both sexes. The inflammatory markers leptin and C-reactive protein were positively correlated (r = 0.67; r = 0.32) and adiponectin was negatively correlated (r = −0.23) with body fat percentage in adolescents of both sexes. Conclusion: In adolescents, the body fat percentage is related to the inflammatory markers leptin, C-reactive protein and adiponectin. It is important to evaluate the body fat composition of adolescents in clinical practice to identify those with a higher percentage of fat, that may reflect an inflammatory profile, as well as increased cardiometabolic risk that accompanies adolescents into adulthood.
Mapping of Congenital Zika virus syndrome, low birth weight and prematurity in Brazil: a spatial analysis
Cíntia Pereira Donateli, Gustavo Bastos Braga, Gabriel Gonçalves Assunção, Jefferson Souza Fernandes, Glauce Dias da Costa
Revista Ra’e ga – Espaço Geográfico em Análise, v. 61, p. 48-61
DOI: 10.5380/raega.v61i1.95646
Resumo: Knowledge and assessment of the consequences, mainly nutritional, that can affect children with Congenital Zika Virus Syndrome (CZS) still need to advance, mainly through spatial approachesthat allow analyzing local vulnerabilities to generate better disease control and monitoring. This study aims to analyze the spatial distribution of CZS cases in Brazilian children and its association with low birth weight and prematurity. This is a retrospective ecological study with anonymized secondary data from the national public health event registration system (RESP-Microcephaly). To verify the existence of spatial association, the Local Indicators of Spatial Association (LISA), univariate and bivariate, were calculated. Therefore, we found that CZS is locally associated with low birth weight and prematurity. Of the 1,834 confirmed cases of CZS from 2015 to 2021 in Brazil that were part of the research universe, 31.2% of babies were born with low weight and 14.7% were premature. Furthermore, the results of LISA’s bivariate analysis show clusters of municipalities with a high incidence of CZS and a high incidence of low birth weight and prematurity in the Northeast region of the country. Finally, our findings demonstrated that there is a spatial association of CZS in Brazil and between CZS and childhood nutritional risks. Given the spatial analysis carried out, this study can contribute to the detection of vulnerable areas with a high incidence of CZS and thus assist in monitoring and evaluating their impacts
Microbiota-Gut-Brain Axis and Impaired Satiety in Individuals with Obesity: A Potentially Bidirectional Association
Mariana de Moura e Dias, Madalena Geralda Cupertino Ribeiro, Ana Claudia Pelissari Kravchychyn & Helen Hermana Miranda Hermsdorff
Current Nutrition Reports, v.14, p.1-10
DOI: 10.1007/s13668-025-00682-9
Fator de impacto: 5.5
Resumo: Purpose of Review. This review aimed to discuss the mechanisms of satiety control related to the neuroendocrine pathways and gut microbiota metabolites, especially in the obesity condition. Physiologically, hormones produced in the cells of the gastrointestinal tract and adipocytes provide feedback to the brain to regulate food consumption. In turn, people living with obesity can present resistance to hormones like leptin and insulin and low-grade inflammation, altering their pre-conditioned functions. Recent Findings. In obesity, there is an imbalance in gut microbiota composition and low-grade chronic inflammation, which alters satiety control mechanisms, leading to increased intestinal permeability, resistance to leptin and insulin, ghrelin dysfunction, and dysregulation of dopamine, serotonin and neuropeptides (inclusing increased orexigenic NPY, and AgRP). Altogether, these disorders result in excessive food consumption and consequent weight gain, generating a causal bidirectional relationship. Short-chain fatty acids (SCFAs), a recognized microbiota metabolite, interact with enteroendocrine L cells, inducing the production of GLP-2, which contributes to the maintenance of tight junctions between intestinal epithelial cells. Additionally, SCFAs activate receptors such as GPR109A, which increases the expression of proteins responsible for tight junctions, thereby preserving the integrity of the intestinal barrier and controlling its permeability. This receptor also participates in immune responses, favouring the release of interleukin-10 (IL-10), a cytokine with anti-inflammatory effects. Summary. Nutritional strategies for the treatment of obesity should be focused not only on reducing calories and consequent adipose tissue but also on modulating neuroendocrine satiety. Foods that modulate the gut microbiota, reducing low-grade chronic inflammation and stimulating the production of intestinal metabolites such as SCFAs, favour satiety control and obesity management not only through the balance of the gut microbiota but also through the activation of intestinal hormones and neuropeptides
Mixed green banana (Musa spp.) pulp and peel flour reduced body weight gain, adiposity, and improved biochemical and intestinal parameters in Wistar rats.
Leonara Martins Viana, Bárbara Pereira da Silva, Fabiana Silva Rocha Rodrigues, Laise Trindade Paes, Marcella Duarte Villas Mishima, Renata Celi Lopes Toledo, Elad Tako, Hércia Stampini Duarte Martino Frederico Barros
Nutrients, v. 17, p.2493-2507.
DOI: 10.3390/nu17152493
Fator de impacto: 5.0
Resumo: Background and Objectives: In recent years, there has been growing interest in the production of ingredients rich in dietary fiber and antioxidants, such as green banana flours. This study evaluated the effect of consumption of mixed green banana pulp (PF) and peel (PeF) flours on the body weight gain, adiposity, lipid profile, and intestinal morphology of Wistar rats. Methods: Male young rats were divided into four groups (n = 8) that received a standard diet (SD), or one of the following three test diets: M1 (SD + 90% PF/10% PeF), M2 (SD + 80% PF/20% PeF), or P (SD + 100% PF) for 28 days. Results: Rats from M1, M2, and P groups showed reduced body weight gain and adiposity and had lower contents of total cholesterol, LDL-c, VLDL-c, and triglycerides. Animals from M1 and M2 groups had an increase in cecum weight, fecal moisture, acetic acid concentration, and crypt depth and reduced fecal pH. Moreover, consumption of the M1, M2, and P diets increased the expression of proteins involved in intestinal functionality. Significant negative correlations were observed between consumption of resistant starch and soluble dietary fiber, from the flours, and weight gain (r = −0.538 and r = −0.538, respectively), body adiposity (r = −0.780 and r = −0.767, respectively), total cholesterol (r = −0.789 and r = −0.800, respectively), and triglycerides (r = −0.790 and r = −0.786, respectively). Conclusions: Mixed green banana pulp and peel flour proved to be a viable alternative as a food ingredient that can promote weight loss, improve lipid profile and intestinal morphology, and minimize post-harvest losses.
Nutritional and technological potential of umbu-caja and soursop co-product flour
Valeria Silva de Lana, Patrícia Nayara Estevam, Thais Barcelos de Castro, Vinícius Parzanini Brilhante de São José, Thais Carvalho Brito-Oliveira, Pedro Henrique Santos, Cristiane Almeida Santos Oliveira, Cristiane Bani Corrêa, Mauricio Ariel Rostagno, Hércia Stampini Duarte Martino, Izabela Maria Montezano de Carvalho
Food Research International, v. 200, p. 115520- 115531
Fator de impacto: 7.0
DOI: 10.1016/j.foodres.2024.115520
Resumo: Umbu-caja and soursop from the Northeast region of Brazil are rich in nutrients and bioactive compounds and are widely processed by the fruit agroindustry. However, there is a lack of research examining the composition and nutritional/technological potential of these co-product fruits. The present study evaluated the nutritional and technological characteristics of umbu-caja and soursop co-product flours (UCF and SCF, respectively), in addition to cytotoxicity in healthy cells. The results demonstrated that they are rich in dietary fiber (approximately 53 %), low in protein (approximately 8.0 %), and have minimal moisture content (<15 %). The mineral composition of the flours exhibited a notable presence of copper, iron, zinc, manganese, and boron. The evaluation of antioxidant capacity using the DPPH, ABTS, and FRAP methods demonstrated the presence of antioxidants that resisted processing, indicated by a high antioxidant capacity. Furthermore, the flours were found to contain phenolic compounds, predominantly rutin (UCF) and p-coumaric acid (SCF). The cytotoxicity test demonstrated that both co-product flours did not exert detrimental effects on healthy cells according to the MTT assay. The technological analyses highlighted low pH values (2.38 and 3.61 for UCF and SCF, respectively), which is favorable for a greater shelf life and suggests applications in fermented products. In addition, the flours have good water and oil holding capacity and low foaming, and they could be incorporated into food products that require these properties. The results demonstrated promising qualities of the UCF and SCF for incorporation into the human diet and product development, mainly due to their high fiber content, antioxidant capacity and low cytotoxicity.
Obesity Incidence According to Branched-Chain Amino Acid Intake and Plant-Based Diet Index Among Brazilian Adults: A Six-Year Follow-Up of the CUME Study
Fernanda Maria Oliveira da Silva, Adriano Marçal Pimenta, Leidjaira Lopes Juvanhol, Helen Hermana Miranda Hermsdorff, Josefina Bressan
Nutrients, v. 17, p. 227- 243
Fator de impacto: 4.8
DOI: 10.3390/nu17020227
Resumo: Background: Few studies have evaluated the impact of branched-chain amino acid (BCAA) intake on the risk of obesity in adults. The results are contradictory, and the causality has not been explored. This study assessed the association between BCAA intake and obesity incidence among Brazilian adults and investigated the potential moderating role of the plant-based index (PDI) in this relationship. Methods: A longitudinal study was conducted between 2016 and 2022, with 3090 participants (2043 women, 1047 men; mean age 34 years) from the Cohort of Universities of Minas Gerais (CUME) Study. Data were collected through an online questionnaire. The relationship between BCAA intake and obesity incidence was assessed using crude and adjusted Cox regression models. Restricted cubic spline analysis (RCS) was used to estimate the nonlinearity. The multiplicative interaction with PDI was tested. Results: The overall incidence of obesity was 192 cases (6.21%). The incidence was 16.4/1000 person-years in females; 21.8/1000 person-years in males; and 18.3/1000 person-years total, with a mean follow-up period of 3.4 years. Compared to the first tertile, the highest intake tertiles for BCAA (HR = 1.50, 95% CI = 1.03–2.18), isoleucine (HR = 1.52, 95% CI = 1.04–2.22), and leucine (HR = 1.51, 95% CI = 1.03–2.20) were independently associated with obesity risk. BCAA intake above 16 g/day increases the risk of obesity. Conclusions: There was a positive association between the intake of BCAA, isoleucine, and leucine with the risk of obesity. The PDI accentuated the association between BCAA intake and obesity in both the lowest and highest quintiles.
Oral intake of Hibiscus sabdariffa L. increased c-Myc and caspase-3 gene expression and altered microbial population in colon of BALB/c mice induced to preneoplastic lesions
Andressa Ladeira Bernardes, Mariana de Fátima Albuquerque Pereira, Iasmim Xisto Campos, Larissa Ávila, Bruna Cristina dos Santos Cruz, Marcella Duarte Villas Mishima, Manoela Maciel dos Santos Dias, Tiago Antônio de Oliveira Mendes, Maria do Carmo Gouveia Peluzio
European Journal of Nutrition, v. 64, p. 1-11
Fator de impacto: 4.1
DOI: 10.1007/s00394-025-03622-z
Resumo: Background: Colorectal carcinogenesis induces changes in the colon, such as the appearance of aberrant crypt foci (ACF). This process is influenced by genetic and environmental factors, such as diet. Hibiscus sabdariffa L. is a considerable source of phenolic compounds, such as anthocyanins, and dietary fibers that may exert anti-inflammatory, antioxidant and prebiotic properties, attenuating the appearance of ACFs. Objectives: To investigate whether supplementation with 5% or 10% of dehydrated calyces of Hibiscus sabadariffa (DHSC) influences the composition of the intestinal microbiota and the expression of genes related to colorectal carcinogenesis in BALB/c mice. Methods: The in vivo experiment lasted 12 weeks and the animals were divided into 3 experimental groups: the control group and the supplemented groups (5% or 10% DCHS) and induced pre-neoplastic lesions with the drug Dimethylhydrazine. Serum aspartate aminotransferase and alanine aminotransferase markers, liver cytokine profile, gut microbiota composition and tumor protein 53, cellular myelocytomatosis oncogene, caspase-3 and Proliferating Cell Nuclear Antigen gene expression were determined. Results: Supplementation with 5% or 10% of DCHS altered the composition of the intestinal microbiota, increasing the abundance of the families Lachnospiraceae, Ruminococcaceae, Clostridiaceae and of the genus Clostridum, important producers of butyrate. Furthermore, 5% and 10% DCHS supplementation increased caspase-3 and c-Myc expression, respectively, which may suggest apoptotic events. Conclusions: Therefore, the effects of DHSC, rich in anthocyanins and dietary fiber, on the composition of the intestinal microbiota and on the expression of genes associated with cell apoptosis may contribute to reducing the risk of developing preneoplastic lesions.
Physicochemical, nutritional, and sensory properties of ready-to-eat whole grain bean snacks.
Francielle Barbosa Pena, Andressa Alvarenga Silva, Jaqueline Maciel Vieira Theodoro, Monique Barreto Santos, Carlos Wanderlei Piler de Carvalho, Hércia Stampini Duarte Martino, Bárbara Pereira da Silva
Food Research International, v.217, p. 116754 – 116762.
DOI: 10.1016/j.foodres.2025.116754
Fator de impacto: 8.0
Resumo: Ready-to-eat snacks are convenient food that can be an interesting nutritious alternative for consumers, serving as a protein source and gluten-free option. The nutritional and physicochemical characterization of snacks from different bean varieties is essential to identify those with the best nutritional value, techno-functionality and sensory properties. This study evaluated the physicochemical, nutritional and sensory properties of four snacks produced from extruded beans: black (BB), red (RB), carioca (CB) and cowpea (CW). Extrusion reduced final viscosity peaks of the snack flours compared to raw bean flours. BB presented the highest content of ash, potassium, calcium, and manganese. RB highlighted in iron content, antioxidant capacity, and phenolic compounds. CB showed the highest sodium content and CW the highest carbohydrate, protein and zinc content. No condensed tannin content was detected in all snacks. Color analysis revealed that BB had darker coloration, reflected in lower lightness (L*), RB presented a higher red coordinate (a*) and CB a higher yellow coordinate (b*). In relation to texture, no difference in special rupture frequency was observed among snacks. However, CW snacks showed higher apparent density, lower longitudinal expansion index and CW showed lower water absorption and water solubility index compared to the others. Sensory evaluation showed no significant differences among the bean snacks. Regarding purchase intention, all snacks showed a score higher than the average. Thus, ready-to-eat expanded whole grain bean snacks showed good physicochemical and nutritional properties, varying according to bean cultivar. These findings highlight their potential as a nutritious and functional alternative for consumption.
Preclinical Evidence on the Impact of Sorghum (Sorghum bicolor) Genotypes, Fractions, and Processing Methods on Intestinal Health: A Review of an Ancient Grain Rich in Phenolic and Dietary Fiber
Vinícius Parzanini Brilhante de São José, Stephanie Michelin Santana Pereira, Álvaro Luiz Miranda Piermatei, Valéria Aparecida Vieira Queiroz, Bárbara Pereira da Silva, Hércia Stampini Duarte Martino e Elad Tako
Critical Reviews in Food Science and Nutrition, v. 2025, p.1–25.
DOI: 10.1080/10408398.2025.2556229
Fator de impacto: 8.8
Resumo: Sorghum (Sorghum bicolor) is an ancient grain and the fifth most produced cereal worldwide, and the most consumed cereal in the semi-arid regions of Africa and Asia, being a key grain for the diet of about 500 million people. It is rich in phenolic compounds (like flavonoids, 3-deoxyanthocyanidins, phenolic acids), resistant starch, and dietary fiber, which may beneficially influence intestinal health. This systematic review analyzed 22 in vivo studies to assess the effects of sorghum processing on bioactive compounds and their effects on intestinal health. Evidence suggests that sorghum modulates microbiota composition, enhances epithelial barrier integrity, improves intestinal morphology, and alters short-chain fatty acid production. These benefits appear to be influenced by sorghum genotype, grain fraction, and processing method, like refinement, extrusion, and fermentation, which affect the bioavailability of phenolics. Some studies indicated the effects of sorghum phenolics on anti-inflammatory and improved tight junction protein expression. Additionally, we emphasized the lack of complete information in several studies by not specifying genotypes, varieties, processing, and profiles of bioactive compounds of the sorghums used, hindering the understanding of the mechanisms involved in improving intestinal health. Overall, this review supports the potential of sorghum as functional food and ingredient for intestinal health promotion.
Processed Pearl Millet Improves the Morphology and Gut Microbiota in Wistar Rats.
Jaqueline Maciel Vieira Theodoro, Lucimar Aguiar da Silva, Vinícius Parzanini Brilhante de São José, Nathaniel Baldwin Willis, Renata Celi Lopes Toledo, Mariana Grancieri, Carlos Wanderlei Piler Carvalho, Joseph Francis Pierre, Bárbara Pereira da Silva and Hércia Stampini Duarte Martino
Foods, v.14, p. 2752 – 2770
DOI: 10.3390/foods14152752
Fator de impacto: 5.1
Resumo: This study evaluated the effect of pearl millet subjected to different processing on the intestinal health of rats. The animals were fed a standard iron-free diet (28 days) (hemoglobin depletion: 8.65 + 1.40 g/dL of hemoglobin). Subsequently, they were divided into four groups for hemoglobin repletion (21 days): standard diet + ferrous sulfate (SD + FS); standard diet + non-germinated open-pan cooked millet flour (SD + NGOPCMF); standard diet + germinated open-pan cooked millet flour (SD + GOPCMF); and standard diet + extrusion-cooked millet flour (SD + ECMF). Hemoglobin level did not differ among groups. The SD + NGOPCMF, SD + GOPCMF and SD + ECMF groups demonstrated a higher Chao index in the microbiome and a higher number and area of goblet cells and longitudinal muscle layer width. The SD + NGOPCMF and SD + GOPCMF groups demonstrated increased cecum weight, crypt depth, crypt thickness, and circular muscle layer width; lower fecal pH; and a higher relative abundance of Bacteroidota, while the SD + FS group showed the highest abundance of Actinobacteriota. The SD + GOPCMF group stood out for showing the lowest fecal pH, better α-diversity (Chao and Shannon index), and the highest width of the longitudinal muscle layer. In conclusion, pearl millet subjected to different processing, mainly germination, has the potential to improve the composition of the intestinal microbiota and the intestinal morphology in rats induced to iron deficiency.
Processo de validação e caraterísticas metodológicas de escalas de percepção da insegurança alimentar: uma revisão de escopo
Jamila da Silva Sultane Aboobacar, Sylvia do Carmo Castro Franceschini, Dayane de Castro Morais, Elizangela da Silva Miguel, Francilene Maria Azevedo, Aline Carare Candido, Silvia Eloiza Priore
Ciência & Saúde Coletiva, v. 30, p. 1-17, 2025.
DOI: 10.1590/1413-81232025308.14692023
Fator de impacto: 1.2
Resumo: Objetivou-se nesta revisão de escopo identificar o processo de validação e as caraterísticas metodológicas das escalas de percepção de insegurança alimentar validadas em diferentes partes do mundo. Realizou-se busca na PubMed, Embase, SciELO, MEDLINE, LILACS e Google Acadêmico, além da literatura cinzenta. A pré-seleção dos estudos se deu pela leitura dos títulos e resumos, seguida pela leitura na íntegra. Dos 828 estudos identificados, foram selecionados 19 referentes a 21 escalas, dos países: Colômbia; Tanzânia; Líbano; Nova Zelândia; Estados Unidos; Equador; Sri Lanka; Brasil; Guatemala; República Dominicana; Haiti; Costa Rica; Venezuela; México; Bolívia; Burkina Faso; e Filipinas, bem como a Escala Latino-americana e Caribenha (ELCSA) e a da FAO. Colômbia e Equador apresentaram duas escalas validadas. As escalas variaram em relação a ano de validação (2000 a 2020), tempo de referência (últimos 3 a 12 meses), número de questões (7 a 18) e tipos de domicílios (urbanos e rurais). Os processos de validação envolveram fases qualitativas e quantitativas. A validação interna se deu pelo coeficiente alfa de Cronbach e o modelo Rasch; e a externa, por associação e/ou correlação com variáveis socioeconômicas e de consumo alimentar. Assim, as escalas identificadas apresentaram processos de validação e caraterísticas metodológicas distintas.
Qualidade da dieta de famílias residentes na zona rural e situação de insegurança alimentar
Dayane de Castro Morais, Luiza Veloso Dutra, Juliana Farias de Novaes, Sylvia do Carmo Castro Franceschini, Silvia Eloiza Priore
DEMETRA: Alimentação, Nutrição & Saúde, v. 20, p. 1-14.
DOI: 10.12957/demetra.2025.78381
Resumo: Introdução: Segurança alimentar e nutricional caracteriza-se pelo acesso regular a alimentos de qualidade e em quantidade suficiente. Objetivo: Verificar relação entre qualidade da dieta de famílias residentes na zona rural e a situação de insegurança alimentar (IA). Método: Trata-se de estudo transversal, com famílias residentes na zona rural de um município da Zona da Mata Mineira. Na análise da qualidade da dieta, pelo índice de alimentação saudável (IAS), considerou-se porções específicas por faixa etária, segundo guias alimentares brasileiros. Calculou-se as médias da pontuação de cada componente do IAS e da pontuação final de todos os integrantes, mantendo o ajuste de densidade energética em 1.000 kcal. A IA das famílias foi avaliada pela Escala Brasileira de Insegurança Alimentar (EBIA). Calculou-se estatística descritiva, correlações de Spearman e teste de Mann-Whitney, considerando a pontuação da qualidade da dieta da família e a situação de IA. Resultados: Nenhuma família atingiu pontuação máxima, indicativa de qualidade, para fruta total, cereal integral e leite e derivados. Observou-se maiores pontuações dos componentes fruta total e inteira, e carne, ovos e leguminosas entre famílias seguras, e maior pontuação para cereais totais em famílias inseguras. Verificou-se correlação negativa entre a pontuação da EBIA e dos componentes fruta total e inteira, carne, ovos e leguminosas e sódio, e positiva com a de cereal total. A pontuação total do IAS nas famílias não diferiu quanto à situação de segurança ou IA. Conclusão: A dieta das famílias residentes na zona rural necessita de melhorias, especialmente daquelas em IA. Metodologias para avaliação da qualidade da dieta em grupos, principalmente na família, devem ser reforçadas.
Regular Consumption of Black Tea Kombucha Modulates the Gut Microbiota in Individuals with and without Obesity
Mirian Aparecida de Campos Costa, Vinícius da Silva Duarte, Gabriela Macedo Fraiz, Rodrigo Rezende Cardoso, Alessandra da Silva, Hércia Stampini Duarte Martino, Carolina Thomaz dos Santos D’Almeida, Mariana Simões Larraz Ferreira, Viviana Corich, Bruce R Hamaker, Alessio Giacomini, Josefina Bressan, Frederico Augusto Ribeiro de Barros
The Journal of Nutrition, v. 155, p. 1331-1349
DOI: 10.1016/j.tjnut.2024.12.013
Fator de impacto: 3.8
Resumo: Background. Kombucha, a fermented beverage obtained from a Symbiotic Culture of Bacteria and Yeast, has shown potential in modulating gut microbiota, although no clinical trials have been done. Objectives. We aimed to evaluate the effects of regular black tea kombucha consumption on intestinal health in individuals with and without obesity. Methods. A pre-post clinical intervention study was conducted lasting 8 wk. Forty-six participants were allocated into 2 groups: normal weight + black tea kombucha (n = 23); and obese + black tea kombucha (n = 23). Blood, urine, and stool samples were collected at baseline (T0) and after 8 wk of intervention (T8). Results. A total of 145 phenolic compounds were identified in the kombucha, primarily flavonoids (81%) and phenolic acids (19%). Kombucha favored commensal bacteria such as Bacteroidota and Akkermanciaceae, especially in the obese group. Subdoligranulum, a butyrate producer, also increased in the obese group after kombucha consumption (P = 0.031). Obesity-associated genera Ruminococcus and Dorea were elevated in the obese group at baseline (P < 0.05) and reduced after kombucha consumption, becoming similar to the normal weight group (Ruminococcus: obese T8 × normal weight T8: P = 0.27; Dorea: obese T8 × normal weight T0: P = 0.57; obese T8 × normal weight T8: P = 0.32). Fungal diversity increased, with a greater abundance of Saccharomyces in both groups and reductions in Exophiala and Rhodotorula, particularly in the obese group. Pichia and Dekkera, key microorganisms in kombucha, were identified as biomarkers after the intervention. Conclusions. Regular kombucha consumption positively influenced gut microbiota in both normal and obese groups, with more pronounced effects in the obese group, suggesting that it may be especially beneficial for those individuals.
Relationship between blood DNA methylation, diet quality indices and metabolic health: Data from Obekit study
Aline Rosignoli da Conceição, Josefina Bressan, Marta Cuervo, Maria Luisa Mansego, J. Alfredo Martínez, José Ignacio Riezu-Boj, Fermín I. Milagro
Journal of Nutritional Biochemistry, v. 136, p. 109805-109817
Fator de impacto: 4.8
DOI: 10.1016/j.jnutbio.2024.109805
Resumo: Epigenetic mechanisms, which can be modulated by dietary factors, have been proposed as a possible factor in understanding interindividual differences in disease susceptibility. We aimed to determine the relationships between DNA methylation (DNAm), diet quality, and metabolic health in Spanish individuals. This is a transversal study encompassing 337 male and female participants in the Obekit study. Diet quality was assessed using a validated semiquantitative food frequency questionnaire and seven previously established scores: overall, healthy and unhealthy Plant-Based Diet Index (PDI, hPDI and uPDI, respectively), dietary diversity score (DDS), unprocessed/minimally processed foods (MPF) and ultra-processed foods (UPF) consumption and Mediterranean diet (MD) score. DNAm was analyzed in white blood cells using the Infinium MethylationEPIC v1.0 BeadChip kit. After filtering by a variance >0.36, we have worked with 5,261 CpG sites. We found four false discovery rate (FDR)-significant correlations between nutrients and CpGs sites: cg00167275 (GLUD1) correlated with alcohol, cg05218090 with folic acid, cg16682935 (PAPSS2) with selenium, and cg09821790 (SLC7A6) with fish food. One differentially methylated region (DMR) located at zinc finger protein gene 57 (ZFP57) was closely related to obesity and specific nutrients, food groups, and diet quality indices. The regression models of diet quality based on DNAm demonstrated that the most predictive values were when UPF and hPDI were considered. Also, UPF and hPDI were the best indices for predicting the main cardiometabolic risk factors. Our finding suggests that specific nutrients and diet quality indices may influence the degree of DNAm and putatively, the metabolic health in Spanish individuals.
Relationship Between Brazilian Dietary Patterns and the Global Syndemic: Data from the CUME Study
Jéssica Bevenuto Mattar, Marcos Heil Costa, Ana Luiza Gomes Domingos, Helen Hermana Miranda Hermsdorff, Adriano Marçal Pimenta, Josefina Bressan
International Journal of Environmental Research and Public Health, v. 22, p. 805-822
Fator de impacto: 4.614
DOI: 10.3390/ijerph22050805
Resumo: Global food systems are contributing to a shift toward unhealthy diets, which is linked to the three components of the global syndemic. This cross-sectional study evaluates how dietary patterns in Brazil are associated with the components of the global syndemic. Anthropometric and food intake data were obtained from the CUME Study—a prospective cohort conducted with a sample of Brazilian university graduates. BMI was used to assess obesity. Insufficient intake of micronutrients was considered undernutrition. Carbon, water, and ecological footprints were used to assess the environmental impact of dietary patterns. Dietary patterns were identified through principal components analysis. Linear regression models were used to evaluate associations between dietary patterns and the components of the global syndemic. The Unhealthy Dietary Pattern was positively associated with BMI and had the highest environmental impact. The Brazilian Dietary Pattern was also positively associated with BMI but had the lowest environmental impact. The Healthy Dietary Pattern was the most protective against micronutrient inadequacy. Diet affected the environment and people’s health in this sample. The dietary patterns identified here as contributing to poor health and environmental damage can help the government develop policies that incorporate the costs of these effects into the prices of food.
Relative monocyte count is associated with metabolic syndrome and other cardiometabolic risk markers in subjects at Secondary Health Care: a cross-sectional study
Flávia Galvão Cândido, Alessandra da Silva, Nathallia Maria Cotta e Oliveira, Gilmara Alves Zanirate, Helen Hermana Miranda Hermsdorff
Diabetes Research and Clinical Practice, v. 226, p.1-10.
DOI: 10.1016/j.diabres.2025.112341
Fator de impacto: 7.4
Resumo: Background: Relative monocyte count (RMC) is a low-cost widely used biomarker with the potential to predict obesity-related health risks. However, high cardiovascular risk could affect white blood cell dynamics. So, we aimed to investigate the associations between RMC with cardiometabolic risk markers in subjects at secondary prevention. Methods: This cross-sectional survey involved 687 subjects at Secondary Health Care. The cardiometabolic risk markers were obesity, metabolic syndrome, high waist circumference, high waist-to-height ratio, hypertension, diabetes, dyslipidemia, high glycated hemoglobin, waist-hypertriglyceridemic phenotype 1 and 2, visceral adiposity index, atherogenic index of plasma, lipid accumulation product, and deep-abdominal-adipose-tissue. Pearson’s chi-square test, binomial, and multiple Logistic regression were adopted (α = 0.05). Results: The first tertile of RMC (<5.20 %) was associated with higher odds of metabolic syndrome (OR 1.62; 95 %CI 1.10–2.17 for NCEP-ATPIII criteria and OR 1.48; 95 %CI 1.01–2.33 for IDF), diabetes (OR 1.68; 95 %CI 1.02–2.76), high glycated hemoglobin (OR 2.31; 95 %CI 1.16–4.59), hypertriglyceridemia (OR 1.57; 95 %CI 1.02–2.40), and waist-hypertriglyceridemic phenotype 1 (OR 1.58; 95 %CI 1.04–2.40) and 2 (OR 1.83; 95 %CI 1.17–2.88), compared to the third tertile, regardless of confounders. Conclusion: The lower RMC tertile was associated with higher odds of cardiometabolic disorders in subjects at secondary prevention.
Reply to S Lv et al
Daniela Mayumi Usuda Prado Rocha, Brenda Kelly Souza Silveira, Josefina Bressan, Helen Hermana Miranda Hermsdorff
Journal of Nutrition, v. 155, p. 657-658
Fator de impacto: 3.7
DOI: 10.1016/j.tjnut.2024.08.003
Sleep quality and duration and frailty in older adults: a systematic review
Ângela Maria Natal de Souza, Dalila Pinto De Souza Fernandes, Isabella Silva Castro, Fernanda Gaspar Gróla, Andréia Queiroz Ribeiro
Frontiers in Public Health, v. 13, p. 1-10, 2025.
Fator de impacto: 3,0
DOI 10.3389/fpubh.2025.1539849
Resumo: Introduction: Sleep problems and frailty are associated with adverse health outcomes in older adults, including mortality, and constitute a major public health challenge. Objective: This study investigated the association between sleep quality and duration and frailty in older adults, with emphasis on methods of evaluation. Methods: This systematic review was guided by the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA). The Embase, Medline (Pubmed) and Cochrane libraries were searched, with no time restrictions for publications. Results and discussion: Of the 17 studies included in this review, all published between 2009 and 2024, 13 were cross-sectional and only four were longitudinal. The Pittsburgh Sleep Quality Index and the Fried phenotype were widely used as methods to assess, respectively, sleep and frailty. Studies evaluating insomnia and frailty by the Fried phenotype all found an independent association. Poor sleep quality was independently associated with pre-frailty and frailty. Sleep onset insomnia, but not sleep maintenance insomnia, was associated with frailty. Short (5 h) and long (9 h) sleep duration were also associated with frailty. Poor sleep quality was associated with pre-frailty and frailty in older adults. The results show a wide diversity of methods for assessing both exposure (sleep quality) and outcome (frailty) and point to a need for further – especially longitudinal – research on the relationship between sleep and frailty.
Soybean Flour Fortified with Gryllus assimilis Powder to Increase Iron Bioavailability Improves Gut Health and Oxidative Balance In Vivo
Michele Lílian da Fonseca Barnabé, Laura Célia de Oliveira Souza Vicente, Karina Vitoria Cipriana Martins, Gabrieli Fernandes Lacerda, Elias Rodrigues, Lívya Alves Oliveira, Kelly Aparecida Dias, Stephanie Michelin Santana Pereira, Vinicius Parzanini Brilhante de São José, Manoela Maciel dos Santos Dias, Ricardo C. Calhelha, Luciano Bernardes Leite, Lúcia Ribeiro, Izabela Maria Montezano de Carvalho, Bárbara Pereira da Silva, Hércia Stampini Duarte Martino, Reggiani Vilela Gonçalves, Ceres Mattos Della Lucia
Nutrients, v. 17, p. 437 -452
Fator de impacto: 4.8
DOI: 10.3390/nu17030437
Resumo: Background: Insects like Gryllus assimilis have an excellent nutritional profile, including iron. However, the bioavailability of this iron and its effects on intestinal health and oxidative balance remain unclear. To enhance acceptance, insects can be used in powder form and combined with common flours. Objective: This study evaluates the effects of Gryllus assimilis powder, alone or with soy flour, on iron bioavailability, intestinal health, and oxidative balance in rodents. Methods: Using the hemoglobin depletion/repletion method, 32 male Wistar rats were divided into four groups: A (standard diet + ferrous sulfate), B (diet + Gryllus assimilis + soy flour), C (diet + Gryllus assimilis), and D (diet + soy flour). Hemoglobin levels, regeneration efficiency, biological value, serum markers, intestinal health, and oxidative balance were assessed. Results: Food intake, weight gain, and bioavailability measures showed no differences. However, the Gryllus + soy group showed higher weekly and final hemoglobin levels than Gryllus alone. This combination also improved acetic acid levels, fecal moisture, and oxidative balance, increasing superoxide dismutase activity while reducing peroxidation products compared to Gryllus alone. Conclusion: These findings highlight the potential benefits of combining Gryllus assimilis with soy flour for iron bioavailability and overall health.
Sustainable extraction of carotenoids from macauba pulp and press‐cake: Use of ethyl acetate and ultrasound as optimization strategies
Danúbia Joanes Rosa Guerra, Caroline Wolffel Silva, Amanda Lais Alves Almeida Nascimento, Paulo César Stringheta, Moysés Naves de Moraes, Ceres Mattos Della Lucia, Frederico Augusto Ribeiro de Barros
Journal of Food Science, v. 90, p. 1-11
Fator de impacto: 3.2
DOI: 10.1111/1750-3841.70030
Resumo: Macauba (Acrocomia aculeata) is a Brazilian palm whose pulp is rich in carotenoids and holds potential for the development of healthy foods. This study presents an innovative approach utilizing ethyl acetate, a solvent recognized as generally safe (GRAS), in conjunction with ultrasound technology, to optimize the extraction of carotenoids from both macauba pulp (MP) and its pulp press-cake (PPC). The effects of varying time and temperature parameters (5–30 min at 25–60°C) alongside ultrasound conditions (25 and 60°C at frequencies of 25 and 45 kHz) on the extraction process were evaluated, with total carotenoid content quantified via spectrophotometry. For MP, the optimal extraction conditions were 60°C for 30 min, yielding 219.33 µg/g of carotenoids, while ultrasound at 45 kHz, under the same time/temperature, enhanced the extraction efficiency to 277.55 µg/g. In the case of PPC, ultrasound extraction achieved a carotenoid content of 124.23 µg/g. Overall, the findings indicate that elevating the temperature to 60°C favored the extraction process, while ultrasound demonstrated effective even under milder conditions. This study emphasizes the potential of ethyl acetate as a sustainable alternative to traditional toxic solvents, aligning with the growing demand for safer and more environmentally friendly practices in the extraction of bioactive compounds.
The bidirectional association between incidence of depression and obesity in Brazilian graduates (CUME study): a 6-year prospective study
Arieta Carla Gualandi Leal, Josefina Bressan, Leidjaira Juvanhol Lopes, Adriano Marçal Pimenta, Helen Hermana Miranda Hermsdorff
International Journal of Food Sciences and Nutrition, v. 2025, p. 1-8
DOI: 10.1080/09637486.2025.2543252
Fator de impacto: 3.3
Resumo: To evaluate the bidirectional relationship between the incidence of depression and obesity in Brazilian graduates. This 6-year longitudinal follow-up study included 3,426 participants from the CUME study in assessing the incidence of obesity and 3,414 participants in assessing the incidence of depression. Risk ratios were estimated and the interaction by sex was tested using the multiplicative method. After an average follow-up of 2.13 years, 387 incident cases of depression and 216 cases of obesity were identified. When stratified by sex, women with an initial diagnosis of depression were at increased risk of developing obesity over time (HR: 2.14; 95% CI: 1.47 − 3.11). The association between initial obesity and incidence of depression was also positive, but only for men (HR: 1.82; 95% CI 1.05 − 3.16). As conclusion, there is bidirectional association for incidence of depression and obesity over time and the risks of developing these diseases are associated differently by sex.
Unhealthy Food Consumption Is Associated with Post-Acute Sequelae of COVID-19 in Brazilian Elderly People
Guilherme José Silva Ribeiro, Rafaela Nogueira Gomes de Morais, Olufemi Gabriel Abimbola, Nalva de Paula Dias, Mariana De Santis Filgueiras, André de Araújo Pinto, Juliana Farias de Novaes
Infectious Disease Reports, v. 17, p. 25-38
Fator de impacto: 3.4
DOI: 10.3390/idr17020025
Resumo: Background/Objectives: The factors associated with post-acute sequelae of COVID-19 (PASC) are not yet fully understood in developing countries. Our objective was to investigate the relationship between food consumption and the occurrence of PASC in Brazilian elderly people. Methods: This cross-sectional study included 1322 elderly people aged 60 or over, infected with SARS-CoV-2 in 2020, living in the state of Roraima in Brazil. Using the Brazilian National Food and Nutrition Surveillance System (SISVAN, in Portuguese) tool, food consumption markers were evaluated. The persistence of post-acute sequelae of COVID-19 was assessed three months after SARS-CoV-2 infection. Poisson regression with robust variance was performed to estimate the prevalence ratio (PR) with a 95% confidence interval (95% CI). Results: Fruit consumption [PR 0.92; 95% CI: 0.85–0.99] was associated with a lower occurrence of PASC, with a significant interaction in individuals aged 60 to 69 years old, not hospitalized, and those without chronic kidney disease. In addition, the consumption of sugar-sweetened beverages [PR 1.23; 95% CI: 1.12–1.35], sandwich cookies, sweets, and treats [PR 1.12; 95% CI 1.03–1.22] was positively associated with the occurrence of PASC in the elderly people, with a significant interaction in individuals living in the capital and without hypercholesterolemia. Conclusions: Unhealthy food consumption was associated with PASC in Brazilian elderly people. An improvement in the diet quality of elderly people is necessary to minimize health complications in PASC.
Vaccination and food consumption: association with Post-Acute COVID-19 Syndrome in Brazilian adults (CUME Study)
Marlise Lima Brandão, Helen Hermana Miranda Hermsdorff, Arieta Carla Gualandi Leal, Josefina Bressan, Adriano Marçal Pimenta
Frontiers in Nutrition, v. 12, p. 1549747-1549759
Fator de impacto: 4.0
DOI: 10.3389/fnut.2025.1549747
Resumo: Background: Post-Acute COVID-19 Syndrome (PACS) is an important sequalae of COVID-19. Then, our objective was to analyze the risk and protective factors for PACS in Brazilian adults participating in the Cohort of Universities of Minas Gerais (CUME Study), with emphasis on COVID-19 vaccination and food consumption. Methods: In this sub-study, we included 2,065 participants of CUME Study who answered the baseline questionnaire in 2016 or 2018 or 2020 or 2022, and the follow-up COVID-19/PACS-specific questionnaire in 2023. PACS diagnosis was based on self-reporting of continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation. To estimate the risk and protective factors for PACS, hierarchical multivariate statistical analysis was conducted using the Cox regression technique, producing two models: (1) focusing on consumption of macro and micronutrients; (2) focusing on consumption of food groups. Results: After a median of 5.5 years of follow-up, 54.4% of the participants
reported PACS. When we analyzed the consumption of macro and micronutrients, higher intake of proteins (HR: 1.36; 95% CI: 1.06–1.74-4th quartile) and lipids (HR: 1.23; 95% CI: 1.02–1.48-4th quartile) were risk factors for PACS. On the other hand, higher intake of vitamin C (HR: 0.78; 95% CI: 0.64–0.94-4th
quartile), vitamin D (HR: 0.81; 95% CI: 0.67–0.99-4th quartile), and zinc (HR: 0.66; 95% CI: 0.52–0.83-4th quartile) were protective factors for the outcome (model 1). When we analyzed the consumption of food groups, higher intake of eggs (HR: 1.59; 95% CI: 1.34–1.89-4th quartile) increased the risk of PACS, whereas, respectively, higher and intermediate consumption of white meat (HR: 0.84; 95% CI: 0.71–1.00-4th quartile) and vegetables (HR: 0.81; 95% CI: 0.67–0.99-2nd quartile; HR: 0.81; 95% CI: 0.67–0.99-3rd quartile) decreased the risk of the outcome (model 2). In both models, pre-infection COVID-19 vaccination was a protective factor for PACS. Conclusion: A healthy diet, with higher consumption of white meat, vegetables and specific micronutrients (vitamin C, vitamin D, zinc), in parallel with preinfection COVID-19 vaccination, is essential to reduce the risk of PACS.
Varal da Saúde Mental e Rodas de Diálogo: técnicas e métodos ativos na investigação qualitativa em saúde e educação
Rosângela Minardi Mitre Cotta, Siomara Aparecida da Silva, Adriana Maria de Figueiredo, Emily de Souza Ferreira, Henriqueta Ilda Verganista Martins Fernandes, Ramón López Martín, Aisllan Diego de Assis
Ciência & Saúde Coletiva, v. 30, p. 1-8, 2025.
DOI: 10.1590/1413-81232025305.02122025
Fator de impacto: 1.2
Resumo: Este artigo objetiva apresentar e descrever as técnicas do varal da saúde mental e da roda de diálogos, como estratégias participativas, dialógicas e significativas da investigação qualitativa em saúde e educação. Considerando a importância de inclusão da diversidade e pluralidade de vozes e experiências, os métodos e técnicas ativas representam uma abordagem ampla e contextualizada para este fim. Trata-se de uma pesquisa qualitativa, que utilizou as duas técnicas ativas e participativas para indagar sobre a saúde mental de educadores de uma comunidade escolar. O “Varal da Saúde Mental” objetiva a compreensão de experiências negativas e positivas relacionadas à saúde mental das pessoas. As “Rodas de Diálogo” são utilizadas como técnicas formativas, promovendo a expressão de sentimentos, pensamentos e comportamentos relacionados à saúde e educação. Os principais núcleos de sentido relacionados às experiências negativas dos educadores foram as vivências de enfermidades e conflitos no trabalho e pessoais. Os positivos foram os relacionamentos pessoais e profissionais e a esperança. A vivência dialógica, levou os participantes a trabalharem os significados a partir de um enfoque mais profundo de saúde mental, produzindo conhecimento sensível com acolhimento.